Simvastatin blunts benefits of exercise in overweight, obese

June 28, 2013
Simvastatin blunts benefits of exercise in overweight, obese
Cholesterol-lowering therapy with simvastatin reduces the physiological responses to aerobic exercise training in overweight or obese adults who are at increased risk for metabolic syndrome, according to research published in the Journal of the American College of Cardiology.

(HealthDay)—Cholesterol-lowering therapy with simvastatin reduces the physiological responses to aerobic exercise training in overweight or obese adults who are at increased risk for metabolic syndrome, according to research published in the Journal of the American College of Cardiology.

Catherine R. Mikus, Ph.D., of Duke University in Durham, N.C., and colleagues studied the effects of statin use on adaptations to exercise training in 37 sedentary overweight or with at least two risk factors for metabolic syndrome, who were randomly assigned to either simvastatin therapy and 12 weeks of training (18 participants) or exercise training alone (19 participants). Cardiorespiratory fitness and mitochondrial content in skeletal muscle were evaluated at baseline and at 12 weeks.

After 12 weeks, the researchers observed a significant increase in cardiorespiratory fitness (10 percent) in the exercise-only group, compared with a non-significant increase (1.5 percent) in the simvastatin + exercise group. Mitochondrial content in skeletal muscle, measured by citrate synthase enzyme activity, increased significantly (13 percent) in the exercise-only group, but decreased by 4.5 percent in the simvastatin + exercise group.

"In conclusion, simvastatin attenuates increases in cardiorespiratory fitness and skeletal muscle mitochondrial content associated with in previously sedentary, overweight, or obese patients at risk of the metabolic syndrome," the authors write. "Given the strong independent cardio-protective effects of increasing cardiorespiratory fitness or lowering low-density lipoprotein cholesterol, the benefits and risks of each should be carefully considered when choosing treatment modalities."

Explore further: Cholesterol-lowering drug may reduce exercise benefits for obese adults, study finds

More information: Full Text (subscription or payment may be required)

Related Stories

Exercise improves metabolic syndrome post-menopause

June 13, 2013

(HealthDay)—Exercise training is associated with improvements in components of metabolic syndrome (MetS) among postmenopausal women, according to a study published in the June 15 issue of The American Journal of Cardiology.

Exercise improves quality of life in type 2 diabetes

March 19, 2013

(HealthDay)—For people with type 2 diabetes mellitus (T2DM), a nine-month aerobic and resistance training program significantly improves quality of life (QOL) compared with no exercise, according to research published online ...

Recommended for you

No silver bullet to beating obesity, study finds

January 10, 2017

As many seek to battle festive bulge in January, new research challenges previous findings that any single aspect of diet or lifestyle can be targeted to reduce the risk of obesity in adults with a high genetic risk of putting ...

Deeper than obesity: A majority of people is now overfat

January 3, 2017

Just in time for those making New Year's resolutions, researchers take a closer look on the current data to suggest up to 76 percent of the world's population is overfat. This amounts to an astonishing 5.5 billion people.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.