Undervaccination appears associated with increased risk of whooping cough
Undervaccination with the diptheria, tetanus toxoids and acelluar pertussis (DTaP) vaccine appears to be associated with an increased risk of pertussis (whooping cough) in children 3 to 36 months of age, according to a study in JAMA Pediatrics by Jason M. Glanz, Ph.D., of the Institute for Health Research at Kaiser Permanente Colorado, Denver.
The study involved children born between 2004 and 2008 and cared for at eight managed care organizations. Each child with laboratory-confirmed pertussis (72 patients) was matched to four randomly selected control patients for a total of 288 controls.
Undervaccincation was defined as missing any of four scheduled doses of the DTaP vaccine. Of 72 case patients with pertussis, 34 (47.22 percent) were undervaccinated for DTaP vaccine by the date of pertussis diagnosis compared to 64 (22.2 percent) of the control patients. Children undervaccinated for three or four doses of DTaP vaccine were 18.56 and 28.38 times more likely, respectively, to have received a diagnosis of pertussis than children who were age-appropriately vaccinated, the study reports.