Tissue repair drug helps heal diabetic foot ulcers

February 25, 2014, The Endocrine Society

Patients were twice as likely to have a diabetic foot ulcer heal within eight weeks when they were treated with a tissue repair drug versus a placebo, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Foot ulcers are a common complication from diabetes than can lead to hospitalization and lower limb amputation. In 2006, about 65,700 non-traumatic lower-limb amputations were performed in people with diabetes, according to the Centers for Disease Control and Prevention. Up to 85 percent of amputations can be avoided when ulcers are prevented from forming or are treated successfully, said one of the study's authors, Francesco Squadrito, MD, of the University of Messina in Gazzi Messina, Italy.

"Foot ulcers are a dangerous and expensive complication for people with diabetes, and current treatments such as hyperbaric oxygen therapy are costly and can have side effects," Squadrito said. "Our study showed for the first time that a pharmacological approach can improve wound healing in people with diabetes."

In the prospective randomized, double-blinded, -controlled clinical trial, 216 participants with free of visible infection were assigned to receive either the tissue repair drug polydeoxyribonucleotide (PDRN) or a placebo. Participants received injections of either PDRN or a placebo for eight weeks and were monitored for an additional four weeks for any change in the ulcer.

After two months, 37 percent of the patients who were treated with PDRN had their ulcers completely closed, compared with nearly 19 percent of the patients who received the placebo. Study subjects reported few side effects from PDRN, Squadrito said.

"This approach could revolutionize the treatment of diabetic – a main cause of hospital admissions in the developed world," he said. "An estimated 382 million people worldwide have , and it is crucial to find effective treatment options for hard-to-heal ulcers and other complications facing millions of patients."

Explore further: Fewer Americans undergoing lower limb amputation

Related Stories

Fewer Americans undergoing lower limb amputation

July 10, 2013
There have been dramatic decreases in the number and severity of lower limb amputations over the past decade, according to a new study published in the July 2013 issue of Foot & Ankle International. At the same time, orthopaedic ...

In Queensland: Diabetes related amputations on the decline

September 2, 2013
Fewer foot and leg amputations are being performed on people with diabetes in Queensland despite a rise in the national rate of diabetes amputations, new analysis has found.

Factors ID'd in healing failure of diabetic foot ulcers

June 15, 2012
(HealthDay) -- Patients with diabetes whose foot ulcers fail to heal have increased inflammation and aberrant growth factor levels, according to a study published online June 11 in Diabetes.

Amputations among people with diabetes can be reduced by 50%, study finds

January 17, 2013
Every 30 seconds somebody in the world is amputated as a consequence of foot complication due to diabetes. A new study at Sahlgrenska Academy, University of Gothenburg, Sweden, confirmes that shoe inserts, podiatry, regular ...

Diabetes-linked amputations declining, study finds

July 19, 2013
(HealthDay)—Fewer foot and leg amputations are being performed on people with diabetes, even as rates of the disease are rising in the United States, a new study finds.

Study links diabetic foot ulcers with higher risk of death, heart attack and stroke

October 10, 2012
(Medical Xpress)—People with diabetes who develop foot ulcers are at more risk of dying prematurely than those without the complication, finds a new large-scale study. The researchers say the findings highlight the potential ...

Recommended for you

Creation of synthetic horsepox virus could lead to more effective smallpox vaccine

January 19, 2018
UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to ...

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Zika virus damages placenta, which may explain malformed babies

January 18, 2018
Though the Zika virus is widely known for a recent outbreak that caused children to be born with microencephaly, or having a small head, and other malformations, scientists have struggled to explain how the virus affects ...

Certain flu virus mutations may compensate for fitness costs of other mutations

January 18, 2018
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations ...

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

Arizona Orthotics
not rated yet Feb 27, 2014
This is fantastic, but lets not forget the need to avoid ulceration as the first line of defense. For your consideration: http://www.prweb....7410.htm

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.