Cancer drug RG7813 launches in its first clinical trial

March 28, 2014, Cancer Research UK

(Medical Xpress)—A new cancer drug, based on further development of a discovery originally made by Cancer Research UK, has entered a clinical trial to target a wide range of cancers.

The drug, RG7813, delivers a cytokine (engineered IL2) to a specific part of the carcinoembryonic antigen (CEA) protein which is exposed only on the surface of , resulting in a narrowly-targeted treatment.

Cancer Research Technology, the commercial arm of Cancer Research UK, licensed the monoclonal antibody called PR1A3 to Roche. PR1A3 was discovered in Sir Walter Bodmer's laboratory when he was director of the Imperial Cancer Research Fund*. Roche has subsequently engineered the antibody and incorporated it into its proprietary immunocytokine drug platform to generate the final drug candidate. Clinical trials have then been initiated.

Sir Walter Bodmer, head of the Cancer and Immunogenetics Laboratory at the University of Oxford, said: "It's very exciting to see that a drug based on our monoclonal PR1A3 antibody is now going into the clinic. By combining these discoveries we make in the lab with the latest developments in immunotherapy, we're expanding our arsenal of at a greater pace – which will ultimately benefit more patients, sooner."

Dr Phil L'Huillier, Cancer Research Technology's director of business management, said: "We're delighted to see the trial launch of this promising new drug, which harnesses the power of the immune system, and that potentially could treat a range of cancers.

"This drug is particularly exciting because it homes in on a new target only accessible on the surface of cancer cells, increasing its potency while sparing healthy cells. We hope that the early prove this is a safe and effective new treatment for cancer patients – ultimately saving more lives from the disease."

Explore further: Cancer Research UK launches trial of new lymphoma treatment

Related Stories

Cancer Research UK launches trial of new lymphoma treatment

January 29, 2014
Cancer Research UK's Drug Development Office (DDO) has launched a new clinical trial to treat lymphoma patients using the body's own immune system to attack cancerous B-cells growing out of control.

New cancer drug shows promise in first trial outside the US

March 10, 2014
(Medical Xpress)—A cancer patient from Bolton with a rare form of Non-Hodgkin's Lymphoma is in remission after becoming the first person outside of the US to trial a new cancer drug, Brentuximab Vedotin, led by University ...

Discovery to help predict who will benefit from lung cancer treatment

March 25, 2014
Cancer Research UK scientists have discovered the structure of an abnormal protein which causes an aggressive type of lung cancer, according to new research* published in the Proceedings of the National Academy of Science ...

Newly engineered monoclonal antibody moves toward clinical testing

January 29, 2014
(Medical Xpress)—Using monoclonal antibodies to fight cancer is a complex, yet promising area of study. At Memorial Sloan Kettering Cancer Center, physician-scientists have focused their attention on expanding the current ...

New imaging approach fast tracks drug testing for incurable prostate cancer

March 17, 2014
Cancer Research UK-funded scientists have developed a new way to test the effectiveness of a drug for prostate cancer that has spread to the bone, which is currently incurable, according to research published in the Journal ...

New trial of personalised cancer treatment begins in Oxford

March 14, 2014
(Medical Xpress)—The first human trial of a pioneering personalised cancer treatment developed at Oxford University will begin this week, with the potential to tackle a wide range of late-stage cancers.

Recommended for you

T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma

January 16, 2018
WASHINGTON-(Jan. 16, 2018)-Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. So, a research team that includes Children's National Health System clinician-researchers ...

Researchers identify new treatment target for melanoma

January 16, 2018
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous ...

More evidence of link between severe gum disease and cancer risk

January 16, 2018
Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists ...

Researchers develop a remote-controlled cancer immunotherapy system

January 15, 2018
A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

Dietary fat, changes in fat metabolism may promote prostate cancer metastasis

January 15, 2018
Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, ...

Pancreatic tumors may require a one-two-three punch

January 15, 2018
One of the many difficult things about pancreatic cancer is that tumors are resistant to most treatments because of their unique density and cell composition. However, in a new Wilmot Cancer Institute study, scientists discovered ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.