New lab records the brain and body in action

March 6, 2014 by Laura Kurtzman, University of California, San Francisco
New lab records the brain and body in action
GlassBrain, a new imaging technology created by Gazzaley's team, creates vivid visualizations of the brain's electrical pulses in real time.

(Medical Xpress)—How does an autistic child take in information when he sits in a classroom abuzz with social activity? How long does it take someone with multiple sclerosis, which slows activity in the brain, to process the light bouncing off the windshield while she drives?

Until recently, the answers to basic questions of how diseases affect the brain – much less the ways to treat them – were lost to the limitations on how scientists could study brain function under real-world conditions. Most technology immobilized subjects inside big, noisy machines or tethered them to computers that made it impossible to simulate what it's really like to live and interact in a complex world.

But now UC San Francisco neuroscientist Adam Gazzaley, MD, PhD, is hoping to paint a fuller picture of what is happening in the minds and bodies of those suffering from brain disease with his new lab, Neuroscape, which bridges the worlds of neuroscience and high-tech.

In the Neuroscape lab, wireless and mobile technologies set research participants free to move around and interact inside 3-D environments, while scientists make functional recordings with an array of technologies. Gazzaley hopes this will bring his field closer to understanding how complex neurological and psychiatric diseases really work and help doctors like him repurpose technologies built for fitness or fun into targeted therapies for their patients.

"I want us to have a platform that enables us to be more creative and aggressive in thinking how software and hardware can be a new medicine to improve brain health," said Gazzaley, an associate professor of neurology, physiology and psychiatry and director of the UCSF Neuroscience Imaging Center. "Often, high-tech innovations take a decade to move beyond the entertainment industry and reach science and medicine. That needs to change."

As a demonstration of what Neuroscape can do, Gazzaley's team created new imaging technology that he calls GlassBrain, in collaboration with the Swartz Center at UC San Diego and Nvidia, which makes high-end computational computer chips. GlassBrain creates vivid, color visualizations of the structures of the brain and the white matter that connects them, as they pulse with electrical activity in real time.

These brain waves are recorded through electroencephalography (EEG), which measures electrical potentials on the scalp. Ordinary EEG recordings look like wavy horizontal lines, but GlassBrain turns the data into bursts of rhythmic activity that speed along golden spaghetti-like connections threading through a glowing, multi-colored glass-like image of a brain. Gazzaley is now looking at how to feed this information back to his subjects, for example by using the data from real-time EEG to make video games that adapt as people play them to selectively challenge weak brain processes.

Gazzaley has already used the technology to image the brain of former Grateful Dead drummer Mickey Hart as he plays a hypnotic, electronic beat on a Roland digital percussion device with NeuroDrummer, a game the Gazzaley Lab is designing to enhance through rhythmic training. Hart, whose brain is healthy, is collaborating with Gazzaley to develop the game and performed on NeuroDrummer while immersed in virtual reality on an Oculus Rift at the Neuroscape lab opening on March 5.

The Neuroscape lab will be available to all UCSF researchers who study the . And Gazzaley ultimately hopes it will aid in the development of therapies to treat diseases as various as Alzheimer's, , attention deficit and hyperactivity disorder, schizophrenia, autism, depression and .

Explore further: Neuroscientists find it's never too late to retrain brain

Related Stories

Neuroscientists find it's never too late to retrain brain

November 2, 2012
(Medical Xpress)—UCSF neuroscientists have found that by training on attention tests, people young and old can improve brain performance and multitasking skills.

Training the older brain in 3-D: Video game enhances cognitive control

September 4, 2013
Scientists at UC San Francisco are reporting that they have found a way to reverse some of the negative effects of aging on the brain, using a video game designed to improve cognitive control.

Real-time insight into our brain

March 4, 2014
Combining two imagine technologies, such as MRI for structure and MEG for activity, could provide a new understanding of our how our brain works.

Retraining the brain -- All is not lost, despite aging, injuries, or mental illness

November 18, 2011
(Medical Xpress) -- Our mature brains may not be so old and inflexible after all. Scientists are discovering that the human brain can improve its performance to counter the consequences of cognitive impairment and even the ...

New study on multitasking reveals switching glitch in aging brain

April 11, 2011
Scientists at the University of California, San Francisco have pinpointed a reason older adults have a harder time multitasking than younger adults: they have more difficulty switching between tasks at the level of brain ...

Recommended for you

Research reveals atomic-level changes in ALS-linked protein

January 18, 2018
For the first time, researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases ...

Fragile X finding shows normal neurons that interact poorly

January 18, 2018
Neurons in mice afflicted with the genetic defect that causes Fragile X syndrome (FXS) appear similar to those in healthy mice, but these neurons fail to interact normally, resulting in the long-known cognitive impairments, ...

How your brain remembers what you had for dinner last night

January 17, 2018
Confirming earlier computational models, researchers at University of California San Diego and UC San Diego School of Medicine, with colleagues in Arizona and Louisiana, report that episodic memories are encoded in the hippocampus ...

Recording a thought's fleeting trip through the brain

January 17, 2018
University of California, Berkeley neuroscientists have tracked the progress of a thought through the brain, showing clearly how the prefrontal cortex at the front of the brain coordinates activity to help us act in response ...

Midbrain 'start neurons' control whether we walk or run

January 17, 2018
Locomotion comprises the most fundamental movements we perform. It is a complex sequence from initiating the first step, to stopping when we reach our goal. At the same time, locomotion is executed at different speeds to ...

Neuroscientists suggest a model for how we gain volitional control of what we hold in our minds

January 16, 2018
Working memory is a sort of "mental sketchpad" that allows you to accomplish everyday tasks such as calling in your hungry family's takeout order and finding the bathroom you were just told "will be the third door on the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.