Visualising plastic changes to the brain

Visualising plastic changes to the brain
The principle of transcranial magnetic stimulation (TMS). A current-carrying coil (top left) generates short lasting (~300 microseconds) magnetic fields which induce electric currents in the cortex. This enables to functionally stimulate or inhibit specific brain regions, here illustrated in a schematic diagram by means of functional magnetic resonance imaging. Credit: Nick J. Davis.

Tinnitus, migraine, epilepsy, depression, schizophrenia, Alzheimer's: all these are examples of diseases with neurological causes, the treatment and study of which is more and more frequently being carried out by means of magnetic stimulation of the brain. However, the method's precise mechanisms of action have not, as yet, been fully understood. The work group headed by PD Dr Dirk Jancke from the Institut für Neuroinformatik was the first to succeed in illustrating the neuronal effects of this treatment method with high-res images.

Painless therapy

Transcranial magnetic stimulation (TMS) is a painless, non-invasive stimulation method, where an electromagnetic coil held above the head is used to generate a strong . This method is deployed to activate or inhibit specific brain regions. Even though the number of its medical applications is constantly on the increase, TMS' precise neuronal mechanisms of action are not, as yet, very well understood. That is because imaging used for humans, such as fMRI (functional magnetic resonance imaging), do not possess the temporal resolution necessary for recording neural activities in milliseconds. More rapid measurement methods, such as EEG or MEG, on the other hand, are affected by the induced magnetic field, with the results that strong interferences are generated that cover important information regarding immediate TMS-based changes to brain activities.

Observing effect on neurons in real time

High-res images of TMS effects have now for the first time been successfully generated by RUB researchers in animal testing. The work group headed by PD Dr Dirk Jancke, Institut für Neuroinformatik, utilises voltage-sensitive dyes which, anchored in cell membranes, send out fluorescent light signals once neurons get activated or inhibited. By using light, the researchers avoided the problem of measurement of artefacts occurring due to magnetic fields. "We can now demonstrate in real time how one single TMS pulse suppresses brain activity across a considerable region, most likely through mass activation of inhibiting brain cells," says Dr Jancke. With higher TMS frequencies, each additional TMS pulse generates an incremental increase in brain activity. "This results in a higher cortical activation state, which opens up a time window for plastic changes," explains Dr Vladislav Kozyrev, the first author of the study.

Chances for patients

The increased neuronal excitability may be utilised to effect specific reorganisation of cell connections by means of targeted learning processes. For example, through visual training after TMS, the ability to identify image contours improves; moreover, a combination of these methods enhances contrast perception in patients with amblyopia - a disorder of sight acquired during child development.

For many of the , such as epilepsy, depression and stroke, specific models have been developed. "Deployed in animal testing, our technology has delivered high spatiotemporal resolution imaging data of cortical activity changes," says Dirk Jancke. "We are hoping that these data will enable us to optimise TMS parameters and learning processes in a targeted manner, which are going to be used in future to adapt this technology for medical treatment of humans."

Explore further

Watching individual neurons respond to magnetic therapy

More information: V. Kozyrev, U.T. Eysel, D. Jancke (2014): "Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics," PNAS, DOI: 10.1073/pnas.1405508111
Citation: Visualising plastic changes to the brain (2014, September 4) retrieved 3 August 2021 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments