Omalizumab effective for chronic spontaneous urticaria

March 31, 2016

(HealthDay)—Omalizumab is effective in patients with moderate-to-severe chronic spontaneous urticaria (CSU) symptoms and angioedema unresponsive to high doses of antihistamine treatment, according to a study published online March 24 in Allergy.

Petra Staubach, M.D., from Universität Mainz in Germany, and colleagues conducted a phase III, multicenter study in which 91 CSU patients with angioedema and wheals were randomized to omalizumab 300 mg or placebo (every four weeks up to week 24).

The researchers found that among the patients completing the 28-week phase (omalizumab, 35; placebo, 33), omalizumab was superior to placebo in improving Chronic Urticaria Quality of Life scores at week 28. Angioedema-burdened days per week improved threefold with omalizumab (0.3) versus placebo (1.1). With omalizumab, the median time to first recurrence of angioedema was 57 to 63 days; with it was less than five days. Omalizumab significantly improved angioedema-specific quality of life.

"Omalizumab was an effective treatment option for with moderate-to-severe CSU symptoms and angioedema unresponsive to high doses of antihistamine treatment," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Novartis, which manufactures omalizumab and funded the study.

Explore further: Omalizumab decreases colds in inner-city children with asthma, study reports

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Omalizumab decreases colds in inner-city children with asthma, study reports

March 6, 2016
Treatment with omalizumab significantly decreases the number of colds in inner-city children with allergic asthma, researchers reported at a press conference today at the American Academy of Allergy, Asthma and Immunology ...

Aspirin may exacerbate chronic urticaria in children

November 10, 2014
(HealthDay)—In some children with chronic spontaneous urticaria (CSU), exacerbations may be caused by hypersensitivity to aspirin, according to research published online Oct. 29 in Allergy.

Better targeting of treatment gives hope to people with severe asthma

March 2, 2016
Around five million people in the UK are currently being treated for asthma. Of these, a quarter of a million are unable to get good control of their condition, resulting in frequent, severe, or even life-threatening attacks. ...

Angioedema induced by new classes of drugs

October 1, 2015
(HealthDay)—Two newer classes of drugs, dipeptidyl peptidase IV (DPP IV) and neprilysin inhibitors, can induce angioedema, according to research published in the October issue of Allergy.

A step forward in the treatment of chronic urticaria

March 20, 2013
An international study involving dermatologists from the Hospital del Mar and Spanish subjects has concluded that a drug normally used to treat severe bronchial asthma caused by allergies (Omalizumab) rapidly eliminates the ...

Asthma drug found highly effective in treating chronic, severe hives and itch

February 24, 2013
An international team of researchers has found that a once-a-month, high-dose injection of a commonly used asthma drug is highly effective in treating teens and adults chronically afflicted with hives and severe, itchy rash. ...

Recommended for you

The 'greying' of T cells: Scientists pinpoint metabolic pathway behind age-related immunity loss

December 13, 2018
The elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Scientists have long known that a weakened immune system is to blame but the exact mechanisms behind ...

Scientists create most accurate tool yet developed to predict asthma in young children

December 13, 2018
Scientists at Cincinnati Children's Hospital Medical Center have created and tested a decision tool that appears to be the most accurate, non-invasive method yet developed to predict asthma in young children.

New genetic study could lead to better treatment of severe asthma

December 12, 2018
The largest-ever genetic study of people with moderate-to-severe asthma has revealed new insights into the underlying causes of the disease which could help improve its diagnosis and treatment.

Researchers discover unique immune cell likely drives chronic inflammation

December 11, 2018
For the first time, researchers have identified that an immune cell subset called gamma delta T cells that may be causing and/or perpetuating the systemic inflammation found in normal aging in the general geriatric population ...

Macrophage cells key to helping heart repair—and potentially regenerate, new study finds

December 11, 2018
Scientists at the Peter Munk Cardiac Centre have identified the type of cell key to helping the heart repair and potentially regenerate following a heart attack.

Study identifies a key cellular mechanism that triggers pneumonia in humans

December 11, 2018
The relationship between influenza and pneumonia has long been observed by health workers. Its genetic and cellular mechanisms have now been investigated in depth by scientists in a study involving volunteers and conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.