Omalizumab effective for chronic spontaneous urticaria

March 31, 2016

(HealthDay)—Omalizumab is effective in patients with moderate-to-severe chronic spontaneous urticaria (CSU) symptoms and angioedema unresponsive to high doses of antihistamine treatment, according to a study published online March 24 in Allergy.

Petra Staubach, M.D., from Universität Mainz in Germany, and colleagues conducted a phase III, multicenter study in which 91 CSU patients with angioedema and wheals were randomized to omalizumab 300 mg or placebo (every four weeks up to week 24).

The researchers found that among the patients completing the 28-week phase (omalizumab, 35; placebo, 33), omalizumab was superior to placebo in improving Chronic Urticaria Quality of Life scores at week 28. Angioedema-burdened days per week improved threefold with omalizumab (0.3) versus placebo (1.1). With omalizumab, the median time to first recurrence of angioedema was 57 to 63 days; with it was less than five days. Omalizumab significantly improved angioedema-specific quality of life.

"Omalizumab was an effective treatment option for with moderate-to-severe CSU symptoms and angioedema unresponsive to high doses of antihistamine treatment," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Novartis, which manufactures omalizumab and funded the study.

Explore further: Omalizumab decreases colds in inner-city children with asthma, study reports

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Omalizumab decreases colds in inner-city children with asthma, study reports

March 6, 2016
Treatment with omalizumab significantly decreases the number of colds in inner-city children with allergic asthma, researchers reported at a press conference today at the American Academy of Allergy, Asthma and Immunology ...

Aspirin may exacerbate chronic urticaria in children

November 10, 2014
(HealthDay)—In some children with chronic spontaneous urticaria (CSU), exacerbations may be caused by hypersensitivity to aspirin, according to research published online Oct. 29 in Allergy.

Better targeting of treatment gives hope to people with severe asthma

March 2, 2016
Around five million people in the UK are currently being treated for asthma. Of these, a quarter of a million are unable to get good control of their condition, resulting in frequent, severe, or even life-threatening attacks. ...

Angioedema induced by new classes of drugs

October 1, 2015
(HealthDay)—Two newer classes of drugs, dipeptidyl peptidase IV (DPP IV) and neprilysin inhibitors, can induce angioedema, according to research published in the October issue of Allergy.

A step forward in the treatment of chronic urticaria

March 20, 2013
An international study involving dermatologists from the Hospital del Mar and Spanish subjects has concluded that a drug normally used to treat severe bronchial asthma caused by allergies (Omalizumab) rapidly eliminates the ...

Asthma drug found highly effective in treating chronic, severe hives and itch

February 24, 2013
An international team of researchers has found that a once-a-month, high-dose injection of a commonly used asthma drug is highly effective in treating teens and adults chronically afflicted with hives and severe, itchy rash. ...

Recommended for you

A Trojan Horse delivery for treating a rare, potentially deadly, blood-clotting disorder

September 21, 2018
In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic ...

Study shows surprise low-level ozone impact on asthma patients

September 21, 2018
A new study led by UNC School of Medicine researchers indicates that ozone has a greater impact on asthma patients than previously thought. The study, published in the Journal of Allergy and Clinical Immunology, recruited ...

Cancer immunotherapy might benefit from previously overlooked immune players

September 20, 2018
Cancer immunotherapy—efforts to boost a patient's own immune system, allowing it to better fight cancer cells on its own—has shown great promise for some previously intractable cancers. Yet immunotherapy doesn't work ...

Gut fungus exacerbates asthma in antibiotic-treated mice

September 20, 2018
A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease, according to a study published September 20 in the open-access journal PLOS Pathogens by ...

Paracetamol use in infancy is linked to increased risk of asthma in some teenagers

September 17, 2018
Children who take paracetamol during their first two years of life may be at a higher risk of developing asthma by the age of 18, especially if they have a particular genetic makeup, according to new research presented at ...

Cord blood clue to respiratory diseases

September 15, 2018
New research has found children born in the last three months of the year in Melbourne may have a greater risk of developing respiratory diseases such as asthma.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.