Study suggests that gut bacteria could help prevent cancer

cancer

Researchers have shown that various types of intestinal bacteria might be factors in both causing and preventing obesity, and in other conditions and diseases. Now, a UCLA study suggests that it could also potentially be used to reduce the risk for some types of cancer.

The research, published online April 13 in the peer-reviewed journal PLOS ONE, offers evidence that anti-inflammatory "health beneficial" gut can slow or stop the development of some types of cancer.

Ultimately, doctors might be able to reduce a person's risk for cancer by analyzing the levels and types of in the body, and then prescribing probiotics to replace or bolster the amount of bacteria with anti-inflammatory properties, said Robert Schiestl, professor of pathology, and radiation oncology at UCLA and the study's senior author.

"It is not invasive and rather easy to do," he said.

Over millions of years, gut bacteria have evolved into both good and bad types: The good ones have anti-inflammatory properties and the bad ones promote inflammation. The human body typically contains about 10 trillion bacterial cells, compared with only 1 trillion human cells.

Schiestl and his colleagues isolated a bacterium called Lactobacillus johnsonii 456, which is the most abundant of the , and which has some pretty useful applications outside of medicine. "Since it is a Lactobacillus strain, it makes excellent yogurt, kefir, kombucha and sauerkraut."

In the UCLA study the bacterium reduced gene damage and significantly reduced inflammation—a critical goal because inflammation plays a key role in many diseases, including cancer, neurodegenerative diseases, heart disease, arthritis and lupus, and in the aging process.

Previous research led by Schiestl presented the first evidence of a relationship between intestinal microbiota and the onset of lymphoma, a cancer that originates in the immune system. The new study explains how this microbiota might delay the onset of cancer, and suggests that probiotic supplements could help keep cancer from forming.

For both studies, Schiestl and his team used that had mutations in a gene called ATM, which made them susceptible to a neurologic disorder called ataxia telangiectasia. The disorder, which affects 1 in 100,000 people, is associated with a high incidence of leukemia, lymphomas and other cancers.

The mice were divided into two groups—one that was given only anti-inflammatory bacteria and the other that received a mix of inflammatory and anti-inflammatory microbes that typically co-exist in the intestines.

In the Cancer Research paper, Schiestl and his team showed that in the mice with more of the beneficial bacteria, the lymphoma took significantly longer to form.

In the new study, the researchers analyzed the metabolites—molecules produced by the gut's natural metabolic action—in the mice's urine and feces. The scientists were surprised to find that the mice that were receiving only the beneficial microbiota produced metabolites that are known to prevent cancer. Those mice also had more efficient fat and oxidative metabolism, which the researchers believe might also lower the risk for cancer.

Among the other results, in the mice receiving only the , lymphoma formed only half as quickly as it did in the other mice. In addition, mice with the good bacteria lived four times longer and had less DNA damage and inflammation.

"Together, these findings lend credence to the notion that manipulating microbial composition could be used as an effective strategy to prevent or alleviate cancer susceptibility," the researchers write. "Remarkably, our findings suggest that composition of the gut microbiota influence and alter central carbon metabolism in a genotype independent manner. In the future, it is our hope that the use of probiotics-containing [supplements] would be a potential chemopreventive for normal humans, while the same type of microbiota would decrease tumor incidence in susceptible populations."


Explore further

Researchers find link between intestinal bacteria and white blood cell cancer

More information: The study's co-authors are Irene Maier of UCLA, Al Fornace and Amrita Cheema of Georgetown University, and James Bornaman of UC Riverside. UCLA has a patent pending on the use of Lactobacillus johnsonii 456 as an anti-inflammatory agent.
Provided by University of California, Los Angeles
Citation: Study suggests that gut bacteria could help prevent cancer (2016, April 13) retrieved 20 March 2019 from https://medicalxpress.com/news/2016-04-gut-bacteria-cancer.html
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Apr 13, 2016
Now that microbiome is on the table, is the medical community finally prepared to take a closer look at the numerous unexpected similarities between the behavior of cancer and that of the most successful parasitic organisms known to exist -- that of the fungal class?

The suggestion has formerly been ridiculed without careful inspection of the correspondences noted in the text, "Cancer is a Fungus". All of the focus has been upon the attempts to act upon this hypothesis, and very little attention has yet to be paid to the fact that the candida fungus is commonly present in tumors.

If cancer is a result of DNA damage, then what in the world is remission?

And how exactly would a person go about ruling out the existence of an opportunistic spore embedded deep within human tissues which only appears when the conditions are right? Anybody who has already worked in the field of mycology is already deeply familiar with the amazing powers of the endospore.

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