HIV infection negatively affects bone acquisition

June 15, 2016

(HealthDay)—HIV infection with T cell activation is associated with lower bone mineral density (BMD) and stiffness, according to a study published online June 10 in the Journal of Bone and Mineral Research.

John S. Manavalan, M.D., from the Columbia University Medical Center in New York City, and colleagues used dual X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HRpQCT) to characterize BMD and microarchitecture in 38 HIV-infected men on antiretroviral therapy (18 perinatally-infected and 20 adolescence-infected) and 20 uninfected men aged 20 to 25 years.

The researchers found that, compared with uninfected men, HIV-infected men had lower DXA derived areal BMD Z-scores and HRpQCT derived volumetric BMD measures. HIV-infected men had higher proportions of activated and senescent CD4+ and CD8+ T cells compared with uninfected men. HIV-infected men had a lower percentage of circulating osteogenic precursor (COP) cells than uninfected men (0.19 ± 0.02 versus 0.43 ± 0.06 percent; P < 0.001); the proportion was also lower in perinatally- versus adolescence-infected men (0.15 ± 0.02 versus 0.22 ± 0.03 percent; P < 0.04). Higher bone stiffness was seen with a higher proportion of COP cells, while a higher proportion of activated CD4+ T cells was associated with decreased BMD and and a lower proportion of COP .

"T cell activation with HIV-infection was associated with decreased numbers of osteogenic precursors as well as lower peak bone mass and strength," the authors write.

One author disclosed financial ties to Gilead and AbbVie.

Explore further: HIV-infected young males have higher rates of bone loss than females

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

HIV-infected young males have higher rates of bone loss than females

March 10, 2016
Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than in females. Researchers led by Grace Aldrovandi, MD, chief of the Division of Infectious Diseases at Children's Hospital Los ...

A bad buzz: Men with HIV need fewer drinks to feel effects

April 20, 2015
Researchers at Yale and the VA Pittsburgh Healthcare System compared the number of drinks that men with HIV infection, versus those without it, needed to get a buzz. They found that HIV-infected men were more sensitive to ...

Erectile dysfunction prevalence higher in HIV-infected men

July 12, 2012
(HealthDay) -- HIV infection in men is a strong, independent predictor of erectile dysfunction (ED), regardless of age and body mass index (BMI), according to a study published in the July issue of The Journal of Sexual Medicine.

Lumbar spine BMD ups Fx risk in women with discordant T-scores

August 18, 2015
(HealthDay)—Lumbar spine (LS) bone mineral density (BMD) increases fracture risk among women with lower LS T-score than femoral neck (FN) T-score, according to a study published online Aug. 4 in the Journal of Bone and ...

Increased anal cancer risk from HIV plus HPV dual infection

December 3, 2013
(Medical Xpress)—Human papillomavirus, or HPV, which can cause cervical cancer in women, is also known to cause anal cancer in both women and men. Now, a study led by researchers at the UCLA School of Nursing has found ...

For men, income linked to changes in bone mineral density

January 5, 2015
(HealthDay)—For men, income, but not self-identified race/ethnicity or genetic ancestry, is associated with annualized percentage changes in bone mineral density (BMD), according to a study published in the December issue ...

Recommended for you

Study suggests a way to stop HIV in its tracks

December 1, 2017
When HIV-1 infects an immune cell, the virus travels to the nucleus so quickly there's not enough time to set off the cell's alarm system.

Discovery puts the brakes on HIV's ability to infect

November 30, 2017
Viewed with a microscope, the virus faintly resembles a pineapple—the universal symbol of welcome. But HIV, the virus that causes AIDS, is anything but that. It has claimed the lives of more than 35 million people so far.

Rising levels of HIV drug resistance

November 30, 2017
HIV drug resistance is approaching and exceeding 10% in people living with HIV who are about to initiate or reinitiate first-line antiretroviral therapy, according to the largest meta-analysis to date on HIV drug resistance, ...

Male circumcision and antiviral drugs appear to sharply reduce HIV infection rate

November 29, 2017
A steep drop in the local incidence of new HIV infections accompanied the rollout of a U.S.-funded anti-HIV program in a large East-African population, according to a study led by researchers at Johns Hopkins Bloomberg School ...

Combination HIV prevention reduces new infections by 42 percent in Ugandan district

November 29, 2017
A study published today in the New England Journal of Medicine provides real-world evidence that implementing a combination of proven HIV prevention measures across communities can substantially reduce new HIV infections ...

Research on HIV viral load urges updates to WHO therapy guidelines

November 24, 2017
A large cohort study in South Africa has revealed that that low-level viraemia (LLV) in HIV-positive patients who are receiving antiretroviral treatment (ART) is an important risk factor for treatment failure.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.