HPV vaccine reduced cervical abnormalities in young women

July 4, 2016, Canadian Medical Association Journal
Electron micrograph of a negatively stained human papilloma virus (HPV) which occurs in human warts. Credit: public domain

Young women who received the human papillomavirus (HPV) vaccine through a school-based program had fewer cervical cell anomalies when screened for cervical cancer, found a new study in CMAJ (Canadian Medical Association Journal).

"Eight years after a school-based HPV vaccination program was initiated in Alberta, 3-dose HPV vaccination has demonstrated early benefits, particularly against high-grade cervical abnormalities, which are more likely to progress to ," writes Dr. Huiming Yang, Medical Officer of Health and Medical Director, Screening Programs, Alberta Health Services, Calgary, Alberta, with coauthors.

Alberta has both a school-based HPV vaccination program and a population-based screening program for cervical cancer. In 2008, the province introduced HPV vaccination for Grade 5 girls (aged 10-11) and a 3-year catch-up program for Grade 9 girls (aged 14-15); in 2014, it was expanded to include boys. The program provides 3 doses of the vaccine that protects against two strains of HPV, which account for 70% of all cases of cervical cancer.

To determine whether HPV vaccination had an impact on Papanicolaou (Pap) test results, Alberta researchers looked at data on the first cohort of women who participated in both the school and cervical cancer screening. The 10 204 women in the study population were born between 1994 and 1997 (aged 18 to 21 years) and lived in the province before 2008.

Of the total, 1481 (14.5%) were cases—that is, they had cervical anomalies detected during screening—and the remaining 8723 (85.5%) were controls—with no cervical abnormalities detected. Among cases, most (1384, 93.5%) had low-grade cervical abnormalities, and the remaining 97 (6.5%) had high-grade abnormalities.

More than half of the study participants (56%) were unvaccinated, and 44% had received 1 or more doses of the HPV before being screened for cervical cancer. Of the women who had been vaccinated, 84% received 3 or more doses. Among the unvaccinated , 16.1% had cervical abnormalities, compared with 11.8% in the fully vaccinated group.

The authors note that effective HPV vaccination with broad uptake will affect the harms and benefits of cervical screening.

"With population-based HPV vaccination, guidelines for cervical cancer screening may need to include a later age for screening initiation age and/or a longer interval between screenings," they write.

The authors hope that their findings and future research will lead to improved primary and secondary prevention efforts, with integration of HPV vaccination and cervical programs.

Explore further: Study finds decreased rates of high-grade cervical lesions in young women

More information: Canadian Medical Association Journal, www.cmaj.ca/lookup/doi/10.1503/cmaj.151528

Related Stories

Study finds decreased rates of high-grade cervical lesions in young women

June 22, 2015
A new analysis indicates that rates of high-grade cervical lesions decreased in young U.S. women after vaccines were made available to protect against human papillomavirus (HPV), but the trend may be due in part to changes ...

Schoolgirl cancer vaccination encourages mothers to attend cervical screening

November 12, 2015
Manchester researchers have shown that the introduction of the HPV vaccination programme for girls has increased uptake for cervical cancer screening by their mothers.

Lack of clarity about HPV vaccine and the need for cervical cancer screening

July 7, 2011
The research will be presented today at the Annual Scientific Meeting of the Society of Academic Primary Care, hosted this year by the Academic Unit of Primary Health Care, University of Bristol.

HPV vaccination is associated with reduced risk of cervical lesions in Denmark

February 19, 2014
A reduced risk of cervical lesions among Danish girls and women at the population level is associated with use of a quadrivalent HPV vaccine after only six years, according to a new study published February 19 in the Journal ...

Expand HPV vaccination programs in Canada to include males

April 25, 2016
Expanding human papillomavirus (HPV) vaccination programs to include males in Canada will help protect them against HPV-related cancers, according to an analysis published in CMAJ (Canadian Medical Association Journal).

HPV vaccine effective in youth with kidney disease, but less so in those with a kidney transplant

April 7, 2016
Human papillomavirus (HPV) vaccination stimulates robust and sustained immune responses in girls and young women with chronic kidney disease (CKD) and those on dialysis, but less optimal responses to the vaccine were observed ...

Recommended for you

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.