Scientists get closer to developing bioartificial kidney

Investigators are getting closer to creating a functional bioartificial kidney, with advances being presented at ASN Kidney Week 2016 November 15-20 at McCormick Place in Chicago, IL.

A bioartificial could replace the need for dialysis or transplantation in the millions of patients with . A key requirement for such a device is the formation of a "living membrane" that consists of a tight kidney cell layer on surfaces and can transport molecules from one side to the other. In their latest work, Dimitrios Stamatialis, PhD (University of Twente, in The Netherlands), Roos Masereeuw, PhD (University of Utrecht, in The Netherlands), and their teams achieved this using conditionally immortalized human renal proximal tubular epithelial cells (ciPTECs) on polyethersulfone-based hollow fiber membranes. They demonstrated that the cell monolayer is indeed functional as a living membrane.

"This study shows the successful development of a living membrane consisting of a reproducible ciPTEC monolayer on hollow fiber membranes, an important step towards the development of a bioartificial kidney device," said Prof. Stamatialis. "The strategies and methods of this work could be relevant to the development of other bioartificial organs, such as a bioartificial liver or bioartificial pancreas, and organs on chips—such as a kidney on , a lung on chip, or a liver on chip."


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Researchers create a 'living kidney membrane'

More information: Study: "Development of a Bioartificial Kidney Device" (Abstract 23)
Citation: Scientists get closer to developing bioartificial kidney (2016, November 19) retrieved 28 January 2020 from https://medicalxpress.com/news/2016-11-scientists-closer-bioartificial-kidney.html
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