Sooner on your feet after hip fracture

An already available drug can help patients get back on their feet more rapidly after a hip fracture, according to an international study published in the Journal of Bone Joint Surgery. The results suggest that treatment with the drug accelerates the healing process in broken bones.

"We have shown that are more mobile and suffer less pain after a when they receive this treatment," says Per Aspenberg, professor of orthopaedics at Linköping University in Sweden, and first author of the study.

The drug tested by the researchers, teriparatide, is based on a naturally occurring hormone, (PTH). Teriparatide is the active ingredient in human PTH and is currently used to treat osteoporosis (brittle bones). The hormone influences .

"Bones contain both cells that break down and cells that create new bone. This hormone stimulates both types, but it has a greater effect on the cells that create new bone, and the skeleton is thus made stronger. Previous work by my research group in animals has shown that the beneficial effect of the is much stronger during the healing of broken bones than it is for the skeleton in general, such as when it is used to treat osteoporosis," says Per Aspenberg.

The study looked at 171 patients with a fracture in the transition between the neck of the femur and its body, known as a pertrochanteric fracture. The patients were assigned at random to one of two groups: those who received teriparatide after the surgery, and those who received another drug commonly used to treat osteoporosis. Neither the patients nor the personnel who administered the tests knew which treatment a particular patient received. The patients carried out a test in which they rose from a chair, walked three metres, turned round, walked back and sat down again. The investigators timed the patients as they carried out the test. Those who received teriparatide moved more rapidly than those in the other group in the months following the surgery. They also estimated the pain they experienced when carrying out the test to be lower.

"It's my conclusion that this study shows clearly that treatment with PTH accelerates the of fractures in such a manner that patients benefit from it. They are able to function better after six weeks and after three months. This is the first time that this has been shown in a scientifically convincing manner," says Per Aspenberg.

The study has been carried out across 17 countries, and was conducted by a pharmaceuticals company with the participation of researchers from the company, hospitals and universities.


Explore further

Research reveals how novel osteoporosis drug increases bone mass

More information: Per Aspenberg et al, Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture, The Journal of Bone and Joint Surgery (2016). DOI: 10.2106/JBJS.15.01217
Citation: Sooner on your feet after hip fracture (2016, November 21) retrieved 28 September 2021 from https://medicalxpress.com/news/2016-11-sooner-feet-hip-fracture.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors