Age modifies impact of resting heart rate on death, CV events

Age modifies impact of resting heart rate on death, CV events
(HealthDay)—The effect of resting heart rate (RHR) on all-cause mortality and cardiovascular events varies with age, according to a study published online Dec. 30 in the Journal of the American Geriatrics Society.

Kuibao Li, M.D., from Capital Medical University in Beijing, and colleagues conducted a involving 6,209 individuals aged 40 years and older without at baseline. Participants were interviewed in 1991 using a standard questionnaire to obtain information on demographics, medical history, and . RHR was categorized according to quartiles.

The researchers found that 840 subjects died and 676 experienced a during a mean follow-up of 8.3 years. In older participants (≥60 years), there was a significant association for higher RHR with all-cause mortality (P trend < 0.001) and cardiovascular events (P trend = 0.002), which was not seen in younger participants (<60 years; both P trend > 0.05). Age had a significant modifying effect on the correlation between RHR and all-cause mortality and cardiovascular events (P interaction < 0.001 and P interaction = 0.002, respectively). After exclusion of individuals who died or had a cardiovascular event during the first two years of follow-up the results were similar.

"High RHR appears to be an independent determinant of all-cause mortality and cardiovascular events in older but not younger individuals," the authors write.


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