Insulin resistance predicts later cognitive decline

Insulin resistance predicts later cognitive decline
(HealthDay)—Higher serum fasting insulin and insulin resistance predict poorer verbal fluency and a steeper decline in future verbal fluency, according to a study published online April 5 issue of Diabetes Care.

Laura L. Ekblad, M.D., from the University of Turku in Finland, and colleagues examined data from the Finnish nationwide, population-based Health 2000 Health Examination Survey and its 11-year follow-up, the Health 2011 study (3,695 participants; mean age at baseline, 49.3 years; 55.5 percent women). The authors sought to assess the roles of homeostatic model assessment of (HOMA-IR), fasting and glucose, glycated hemoglobin, and high-sensitivity C-reactive protein (hs-CRP) as predictors of cognitive performance.

The researchers found that higher baseline HOMA-IR and fasting were independent predictors of poorer verbal fluency performance (P = 0.0002 for both) and of a greater decline in verbal fluency over follow-up (P = 0.004 for both). Word-list learning and word-list delayed recall scores were not predicted by baseline HOMA-IR or insulin. There were no interactions between cognitive test performance and HOMA-IR and apolipoprotein E ε4 genotype, hs-CRP, or type 2 diabetes. Baseline levels of fasting glucose and hs-CRP levels were not associated with cognitive functioning.

"Prevention and treatment of insulin resistance might help reduce later in life," the authors write.

Explore further

Insulin resistance may lead to faster cognitive decline

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2017 HealthDay. All rights reserved.

Citation: Insulin resistance predicts later cognitive decline (2017, April 10) retrieved 24 June 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more