Sperm study reveals testes repair cells

sperm
Human sperm stained for semen quality testing in the clinical laboratory. Credit: Bobjgalindo/Wikipedia

Scientists have discovered a tiny group of cells that is critical to repairing damage to the testes. Blocking the cells prevents repair to tissue involved in producing healthy sperm, the research has found. The findings shed light on mechanisms of cell repair and could help scientists develop ways to preserve fertility, which may benefit boys receiving cancer therapy.

Damage

Male testes are extremely sensitive to damage from external factors such as radiation and chemotherapy used to treat cancer, which can lead to infertility. Damage can be repaired by internal cell mechanisms, although the process is not fully understood.

Using molecular tools, the research team removed the newly-discovered cells – known as Miwi2-expressing cells – in a group of mice. Unlike their healthy littermates, mice without Miwi2-expressing cells were not able to repair injury, highlighting their critical role in regeneration.

Stem cells

The research – led by the University of Edinburgh – also showed that Miwi2-expressing cells develop surprising features in response to , making them behave like . Stem are known for their central role in tissue repair. Insights from the study may assist future infertility options for pre-pubescent boys undergoing cancer treatment and for whom sperm banking is not an option.

The study – supported by the European Research Council – was carried out in collaboration with the University of Oxford and the European Molecular Biology Laboratory in Italy. The findings are published in the Journal of Experimental Medicine.


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More information: Claudia Carrieri et al. A transit-amplifying population underpins the efficient regenerative capacity of the testis, The Journal of Experimental Medicine (2017). DOI: 10.1084/jem.20161371
Journal information: Journal of Experimental Medicine

Citation: Sperm study reveals testes repair cells (2017, May 3) retrieved 24 January 2021 from https://medicalxpress.com/news/2017-05-sperm-reveals-cells.html
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