Omega-3 fatty acid stops lupus trigger, but how?

June 1, 2017 by James Pestka , Sarina Gleason, Michigan State University
Credit: Michigan State University

Michigan State University scientists have received a $2.3 million, five-year National Institutes of Health grant to help uncover why an omega-3 fatty acid, known as DHA, is so effective in stopping a known trigger of lupus.

Previous MSU research has shown that consuming DHA, or docosahexaenoic acid, which is found in fatty, cold-water fish, can stop the onset of when the is caused by a toxic mineral that's inhaled and typically found around construction, agriculture and mining sites.

It's still unclear, though, how the natural fatty substance prevents the disease from forming.

"When lupus is triggered by fine inhalable particles called crystalline in the lungs, our earlier research has shown that DHA essentially stopped the activation of the disease," said James Pestka, a University Distinguished Professor of food science and human nutrition.

He is leading the new study with MSU co-investigators Jack Harkema, a pulmonary pathologist, and Jenifer Fenton, a nutritional biochemist.

According to Harkema, the DHA could be changing the way these react to the silica in the lungs and somehow stops the immune system from overcompensating and going after healthy cells too.

One theory the researchers have is the DHA could help cells send a signal to the body so it won't overreact and tell the immune system to attack beyond what's needed. Another thought is somehow the DHA allows the cells to swallow up and remove the toxic silica from the lungs without dying, preventing any inflammatory signals from being sent throughout the body.

"Cells in the can gobble up the silica, but it's so toxic, it usually kills these cells," Harkema said. "When they die, signals are sent out to the immune system that something is wrong. The body then produces such a strong response that it also starts killing ."

Their earlier research looked at the effect of DHA on lupus lesions in the lungs and kidneys of female mice that were already genetically predisposed to the disease. The results were overwhelmingly positive.

"Ninety-six percent of the lung lesions were stopped with DHA after being triggered by the silica," Harkema said.

Lupus is considered a genetic disease and is activated not only by inhaling toxic particles in the air, but also by other environmental factors such as sun exposure, cigarette smoking, oral contraceptives and postmenopausal hormone therapy.

"Lupus is the body's immune system attacking itself and it can damage any part of the body including skin, joints and organs," Pestka said. "This new research will let us see what happens at the cellular level in the triggering of lupus and how we can intervene nutritionally with DHA to prevent the flaring and progression of the disease."

Pestka added that the project will also give additional insight on how other respiratory substances more commonly found in the air we breathe, such as diesel exhaust, might trigger the disease.

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BubbaNicholson
1 / 5 (2) Jun 02, 2017
In dietary quantity a jumble of C-C-C=C-C-C=C-C-C=C-C-C=C-C-C=C-C-C=C-C-C-COOH DHA (all cis) looks like human skin surface lipid pheromone, here are a few components (100s more).
C-C-C-C-C-C-C-C-C-C-C-C-C-C-C-COOH Palmitic acid
C-C-C-C-C-C-C-C-C-C=C-C-C-C-C-COOH cis-Hexadec-6-enoic a.
C-C-C-C-C-C-C-C-C-C=C-C-C-C-C-C-C-COOH cis-Octadec-8-enoic a.
C-C-C-C-C-C-C-C-C-C-C-C-C-COOH Myristic a.
C-C-C-C-C-C-C-C-C-C=C-C-C=C-C-C-C-C-C-COOH cis-eicos-7,10-dienoic a.
C-C-C-C-C-C-C-C-C-C-C-C=C-C-C-C-C-COOH cis-Octadec-8-enoic a.
C-C-C-C-C-C-C-C-C-C=C-C-C=C-C-C-C-COOH Sebaleic acid
C-C-C-C-C-C-C-C-C-C=C-C-C-C-C-COOH Sapienic a.
C-C-C-C-C-C-C-C-C-C-C-C-C-C-C-C-COOH Heptadecanoic a.
C-C-C-C-C-C-C-C-C=C-C-C-C-C-C-C-COOH cis-Heptadec-8-enoic a.
C-C-C-C-C-C-C-C-C-C=C-C-C-C-C-COOH cis-14-Methylhexadec-6-enoic a.
/
C
Brain detects pheromone = higher social status, so your are worth saving.
BubbaNicholson
1 / 5 (2) Jun 02, 2017
Dietary quantities of a chemical that resembles one or more of the human pheromone can have pheromonal effects. What we see from dietary quantities of DHA is a pheromonal effect. The pheromone tells the brain that the brain is in a person who is beloved by his/her community/family. When something like this happens, we conclude that a disease is approachable with human pheromone therapy.
Like hormones, pheromones frequently act in opposition. Treatment with 250mg of healthy adult male facial skin surface lipids may benefit lupus, as well as the skin lipids of women, children, babies, and neonates (vernix caseosa). Enhance receptivity with Moslem prayer ritual, or show a sad movie, like "All Mine to Give". Emotional tears contain pheromone receptor proteins and ions sequestered thereby which are released on pheromone contact to alter voltage.
Use oscillating fans, staff to use supplied air respirators, store pheromone in barrier packaging with activated charcoal dunnage.
Captain Stumpy
1 / 5 (1) Jun 03, 2017
@fraudulent bubba the pseudoscience cult "oxymoronic" quack
Treatment with 250mg of healthy adult male facial skin surface lipids may benefit lupus
1- you make the exact same claim for PTSD, autism, and a host of other problems that are completely unrelated

2- you have provided absolutely no empirical evidence whatsoever supporting your claims

3- in reality, there is not a single reputable peer reviewed study that even tangentially supports your delusional claims

4- pseudoscience is not science, it is religion: as you demonstrate, you make the same snake oil potion for everything regardless of the problem - that makes you a fraud

BubbaNicholson
1 / 5 (2) Jun 03, 2017
"@fraudulent bubba the pseudoscience cult "oxymoronic" quack"
An oxymoron is a contradiction in terms.
"1- you make the exact same claim for PTSD, autism, and a host of other problems that are completely unrelated"
Obviously, the sociopathy is related.
"2- you have provided absolutely no empirical evidence whatsoever supporting your claims"
Empirical evidence is required, but difficult to obtain. My last double blind cross over placebo controlled clinical trial blew up due to inadvertent staff reception of the human sub-pheromone.
"3- in reality, there is not a single reputable peer reviewed study that even tangentially supports your delusional claims" Pheromones that work in opposition include puberty delay pheromone and puberty acceleration pheromone. Go look that one up, my book is full of them. My work is novel.
Pseudoscience makes untestable hypotheses. You can go test this hypothesis by wiping male face grease pheromone off your face and giving it to lupus patients.
Captain Stumpy
not rated yet Jun 03, 2017
@fraudulent bubba the pseudoscience cult "oxymoronic" quack
An oxymoron is a contradiction in terms
notice those quote marks?
it's a quote from you, jeenyous
Obviously, the sociopathy is related
and you can show this?
well then, please link or state your references and studies for validation!
but difficult to obtain
yeah, because real labs and hospitals don't allow pseudoscience to be "tested" in them
inadvertent staff reception of the human sub-pheromone
LOL
obvious bullsh*t is obvious
Go look that one up, my book is full of them
first please give demonstrable validated verifiable evidence that human pheromones even exist, considering the following study: http://rspb.royal...full.pdf

so that makes you a fraud (still)
Pseudoscience makes untestable hypotheses
you forgot about prediction and validation (and a few other things)
and to be sure, there are no valid tests either

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