In mice, calorie restriction reduces fat but increases fur

September 12, 2017, Cell Press
This visual abstract depicts the findings of Forni et al., who show that caloric restriction changes the structure and metabolism of the skin; these changes affect whole-bodythermoregulation. Credit: Formi et al./Cell Reports 2017

Calorie restriction may help mice stay slim and live longer, but it also means less fat to keep their bodies warm. Researchers in Brazil have found that mouse skin responds to caloric restriction by stimulating fur growth, increasing blood flow, and altering cell metabolism to increase energy efficiency. The study, published September 12 in the journal Cell Reports, reveals that animals may use this as an evolutionary adaptation to stay warm—and alive—in limited food conditions.

"The changes in the fur and skin were quite noticeable, and are interesting because they were visible after only a few months, when animals are not yet old," says senior author Alicia Kowaltowski, a professor at the University of Sao Paulo's Institute of Chemistry. "The changes may be related to an increase in skin stem , which help preserve the skin from the effects of aging, which we were also able to detect."

A calorie-restricted diet has already been associated with a long list of health benefits, from increasing lifespan and reducing insulin resistance to helping to fight cancer, but its effects on skin have been understudied. To learn more, her group, including postdoctoral fellow Maria Fernanda Forni, who studies , paired up with Jorge Shinohara in Sao Paulo's Fundamental Chemistry Department, who built a custom-made temperature sensor for mouse skin.

They compared mice that could eat everything they wanted, at any time—which meant they eventually became overweight—with animals restricted to eat 60% of the calories of what their more indulgent counterparts were allowed for six months. The calorie-restricted mice lost around half of their body mass and displayed more even, thicker, and longer fur coats.

A mouse on an ad libitum diet, meaning it could choose when and how much to eat. Credit: Maria Fernanda Forni

The group observed that, at the cellular level, one of the side effects of the diet was an expansion of hair follicle stem cells, leading to increasing hair follicle growth and retention rates. Compared to the free-ranging mice, the calorie-restricted mice also had three times as many blood vessels in their skin, to bring more warm blood to the surface, and their skin cells exhibited differences in metabolism so that they lost less energy as heat over time.

The researchers then shaved patches of fur off of mice from both groups to confirm that the extra hair helps warm the calorie-restricted animals. Indeed, based on heat loss measurements, the thicker fur coats helped insulate heat, and without the adaption, the calorie restricted were more lethargic and showed signs of disrupted metabolism.

A mouse on a calorie restriction diet, meaning it ate 60 percent of the calories of an ad libitum group. Credit: Maria Fernanda Forni

"These findings are especially significant since they unveil not only a striking effect of on the skin but also an adaptive mechanism to cope with reduced insulation derived from skin changes under conditions of reduced caloric intake," Kowaltowski says. "I think the research community will be interested in thinking about the skin and fur as integral players in metabolic responses and control."

Her group now wants to focus on understanding the signals involved in promoting the changes in skin they observed with calorie restriction. Kowaltowski says that if we understand these pathways, we could uncover targets to keep the healthy during aging.

Explore further: Link between biological clock and aging revealed: Study shows low-calorie diet may help keep body young

More information: Cell Reports, Forni et al: "Caloric Restriction Promotes Structural and Metabolic Changes in the Skin." http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31177-4 , DOI: 10.1016/j.celrep.2017.08.052

Related Stories

Link between biological clock and aging revealed: Study shows low-calorie diet may help keep body young

August 10, 2017
Scientists studying how aging affects the biological clock's control of metabolism have discovered that a low-calorie diet helps keep these energy-regulating processes humming and the body younger.

How a low-calorie diet could extend lifespan

June 29, 2016
Overeating can lead to health issues that can shorten one's life, such as obesity, diabetes and heart disease. On the other end of the spectrum, several studies have shown that restricting calorie intake below what a normal ...

Consuming fewer calories reduces the risk of abdominal aortic aneurysm

September 26, 2016
Mice placed on a low-calorie diet are less likely to develop abdominal aortic aneurysms, according to a new study in The Journal of Experimental Medicine. The paper, "Calorie restriction protects against experimental abdominal ...

Eat fat, live longer? Mouse study shows a high fat diet increases longevity, strength

September 5, 2017
As more people live into their 80s and 90s, researchers have delved into the issues of health and quality of life during aging. A recent mouse study at the UC Davis School of Veterinary Medicine sheds light on those questions ...

How calorie restriction may prolong life

May 3, 2017
A new review proposes a theory to explain how calorie restriction can extend life across a variety of species.

Scientists identify a new way to activate stem cells to make hair grow

August 14, 2017
UCLA researchers have discovered a new way to activate the stem cells in the hair follicle to make hair grow. The research, led by scientists Heather Christofk and William Lowry, may lead to new drugs that could promote hair ...

Recommended for you

Long-term estrogen therapy changes microbial activity in the gut, study finds

June 20, 2018
Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found.

Researchers use AI to improve mammogram interpretation

June 20, 2018
In an effort to reduce errors in the analyses of diagnostic images by health professionals, a team of researchers from the Department of Energy's Oak Ridge National Laboratory has improved understanding of the cognitive processes ...

Are you sticking to your diet? Scientists may be able to tell from a blood sample

June 19, 2018
An analysis of small molecules called "metabolites" in a blood sample may be used to determine whether a person is following a prescribed diet, scientists at Johns Hopkins Bloomberg School of Public Health have shown.

Everything big data claims to know about you could be wrong

June 19, 2018
When it comes to understanding what makes people tick—and get sick—medical science has long assumed that the bigger the sample of human subjects, the better. But new research led by UC Berkeley suggests this big-data ...

Diagnosing and treating disorders of early sex development

June 19, 2018
Diagnosing, advising on and treating disorders of early sex development represent a huge medical challenge, both for those affected and for treating physicians. In contrast to the earlier view, DSD (Difference of Sex Development) ...

BPA can induce multigenerational effects on ability to communicate

June 18, 2018
Past studies have shown that biparental care of offspring can be affected negatively when females and males are exposed to bisphenol A (BPA); however, previous studies have not characterized how long-term effects of BPA exposure ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.