New treatment significantly improved bladder activity after spinal cord injury

New treatment significantly improved bladder activity after spinal cord injury
Credit: Mary Ann Liebert, Inc., publishers

Researchers have shown that compared to placebo, a drug treatment intended to prevent remodeling of the bladder wall and given within 48 hours after spinal cord injury (SCI) in dogs was associated with significantly higher bladder compliance. The long-term improvement seen in animals that had experienced intervertebral disc herniation and were treated with blockade of matrix metalloproteinases (MMPs) is reported in the Journal of Neurotrauma.

Jonathan Levine, DVM and coauthors from the College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX and University of California, San Francisco designed a study to assess the effectiveness of the broad spectrum MMP inhibitor GM6001 in dogs with naturally occurring that are often accompanied by decreased bladder compliance, in which the cannot stretch normally and pressure increases at lower fluid volumes. Reduced compliance is a major contributor to complications such as , pyelonephritis, and ureteral reflux, as the researchers explain in the article entitled "Early Blockade of Matrix Metalloproteinases in Spinal-Cord-Injured Dogs Results in a Long-Term Increase in Bladder Compliance.

"This study reports on an exciting treatment for canines with low bladder compliance due to spontaneous spinal cord injury. Not only can this drug be potentially used by veterinarians as a therapy, but there is also the possibility of translating this treatment to the clinical SCI population as well," says W. Dalton Dietrich, III, PhD, Deputy Editor of Journal of Neurotrauma and Professor, University of Miami Miller School of Medicine, Miami, Florida.


Explore further

New standards proposed for reporting spinal cord injury experiments

More information: Jonathan M. Levine et al, Early Blockade of Matrix Metalloproteinases in Spinal-Cord–Injured Dogs Results in a Long-Term Increase in Bladder Compliance, Journal of Neurotrauma (2017). DOI: 10.1089/neu.2017.5001
Journal information: Journal of Neurotrauma

Citation: New treatment significantly improved bladder activity after spinal cord injury (2017, September 8) retrieved 21 August 2019 from https://medicalxpress.com/news/2017-09-treatment-significantly-bladder-spinal-cord.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more