New treatment significantly improved bladder activity after spinal cord injury

September 8, 2017, Mary Ann Liebert, Inc
Credit: Mary Ann Liebert, Inc., publishers

Researchers have shown that compared to placebo, a drug treatment intended to prevent remodeling of the bladder wall and given within 48 hours after spinal cord injury (SCI) in dogs was associated with significantly higher bladder compliance. The long-term improvement seen in animals that had experienced intervertebral disc herniation and were treated with blockade of matrix metalloproteinases (MMPs) is reported in the Journal of Neurotrauma.

Jonathan Levine, DVM and coauthors from the College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX and University of California, San Francisco designed a study to assess the effectiveness of the broad spectrum MMP inhibitor GM6001 in dogs with naturally occurring that are often accompanied by decreased bladder compliance, in which the cannot stretch normally and pressure increases at lower fluid volumes. Reduced compliance is a major contributor to complications such as , pyelonephritis, and ureteral reflux, as the researchers explain in the article entitled "Early Blockade of Matrix Metalloproteinases in Spinal-Cord-Injured Dogs Results in a Long-Term Increase in Bladder Compliance.

"This study reports on an exciting treatment for canines with low bladder compliance due to spontaneous spinal cord injury. Not only can this drug be potentially used by veterinarians as a therapy, but there is also the possibility of translating this treatment to the clinical SCI population as well," says W. Dalton Dietrich, III, PhD, Deputy Editor of Journal of Neurotrauma and Professor, University of Miami Miller School of Medicine, Miami, Florida.

Explore further: New standards proposed for reporting spinal cord injury experiments

More information: Jonathan M. Levine et al, Early Blockade of Matrix Metalloproteinases in Spinal-Cord–Injured Dogs Results in a Long-Term Increase in Bladder Compliance, Journal of Neurotrauma (2017). DOI: 10.1089/neu.2017.5001

Related Stories

New standards proposed for reporting spinal cord injury experiments

August 6, 2014
The difficulty in replicating and directly comparing and confirming the scientific results reported by researchers worldwide who are studying new approaches to treating spinal cord injuries is slowing the translation of important ...

Miami project presents data demonstrating therapeutic potential of SRK-015 in SCI

July 10, 2017
The Miami Project to Cure Paralysis, a Center of Excellence at the University of Miami Miller School of Medicine, in collaboration with Scholar Rock, a biotechnology company focused on discovering and developing drugs that ...

Health behaviors and management critical for spinal cord injury patients

August 11, 2016
It can happen in a split second from a vehicle crash, a fall or a gunshot: a person's spinal cord tissue is bruised or torn by a shocking blow.

Transplanted stem cells help prevent bladder fibrosis after spinal cord injury

September 3, 2014
A team of researchers from Korea and Canada have found that transplantation of B10 cells (a stable immortalized human bone marrow derived –mesenchymal stem cell line; B10 hMSC) directly into the bladder wall of mice modeled ...

Potential target for restoring ejaculation in men with spinal cord injuries or ejaculatory disorders

December 5, 2016
New research provides insights on how to restore the ability to ejaculate in men who are not able to do so.

Recommended for you

Mechanisms of harmful overhydration and brain swelling

May 22, 2018
We are all familiar with the drawbacks of dehydration, but we rarely hear about the harmful effects of overhydration. For one, excess fluid accumulation can lead to dangerously low sodium levels in the blood or hyponatremia—a ...

Mice brain structure linked with sex-based differences in anxiety behavior

May 22, 2018
Using male individuals has long been a tradition in scientific mice studies. But new research enforces the importance of using a balanced population of male and female mice.

Cell types underlying schizophrenia identified

May 22, 2018
Scientists at Karolinska Institutet in Sweden and University of North Carolina have identified the cell types underlying schizophrenia in a new study published in Nature Genetics. The findings offer a roadmap for the development ...

In brain stimulation therapy less might be more

May 22, 2018
One of the promising non-invasive brain therapeutic methods is the repetitive transcranial magnetic stimulation (rTMS). During such a procedure, a magnetic coil is placed near the head of the patient and a magnetic pulse ...

Subtle hearing loss while young changes brain function, study finds

May 22, 2018
Cranking up your headphones or scrambling for a front-row spot at rock shows could be damaging more than your hearing.

What helps form long-term memory also drives the development of neurodegenerative disease

May 22, 2018
Scientists have just discovered that a small region of a cellular protein that helps long-term memories form also drives the neurodegeneration seen in Amyotrophic Lateral Sclerosis (ALS). This small part of the Ataxin-2 protein ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.