Psychostimulant use tied to placental complications

November 15, 2017

(HealthDay)—Psychostimulant use during pregnancy is associated with a small increased relative risk of preeclampsia and preterm birth, according to a study published online Nov. 7 in Obstetrics & Gynecology.

Jacqueline M. Cohen, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues examined data from a cohort of pregnant women and their liveborn neonates enrolled in Medicaid (from 2000 to 2010) to assess whether psychostimulants used to treat attention-deficit/hyperactivity disorder (ADHD) are associated with risk of adverse placental-associated outcomes. They compared women who received amphetamine-dextroamphetamine (n = 3,331) or methylphenidate monotherapy (n = 1,515) in the first half of pregnancy to those who received atomoxetine, a nonstimulant ADHD medication, as a negative control exposure (n = 453) and 1,461,493 unexposed pregnancies.

The researchers found that the adjusted risk ratio for stimulant use was 1.29 for preeclampsia (95 percent confidence interval [CI], 1.11 to 1.49), 1.13 for (95 percent CI, 0.88 to 1.44), 0.91 for small for gestational age (95 percent CI, 0.77 to 1.07), and 1.06 for (95 percent CI, 0.97 to 1.16). The adjusted risk ratio for continuation of stimulant use in the latter half of pregnancy (n = 1,319) was 1.26 for preeclampsia (95 percent CI, 0.94 to 1.67), 1.08 for placental abruption (95 percent CI, 0.67 to 1.74), 1.37 for small for (95 percent CI, 0.97 to 1.93), and 1.3 for preterm birth (95 percent CI, 1.1 to 1.55) compared with discontinuation (n = 3,527).

"The absolute increases in risks are small and, thus, women with significant ADHD should not be counseled to suspend their ADHD treatment based on these findings," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Prenatal exposure to ADHD meds tied to neonatal morbidity

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Prenatal exposure to ADHD meds tied to neonatal morbidity

November 13, 2017
(HealthDay)—Exposure to attention-deficit/hyperactivity disorder (ADHD) medication during pregnancy is associated with increased risk of neonatal morbidity, according to a study published online Nov. 10 in Pediatrics.

Eclampsia tied to increased relative risk of seizure disorder

November 10, 2017
(HealthDay)—The relative risk of a seizure disorder after eclampsia is higher than that of women unaffected by eclampsia but remains extremely low, according to a study published online Nov. 7 in Obstetrics & Gynecology.

Risk of certain adverse outcomes up with endoscopy in pregnancy

February 7, 2017
(HealthDay)—Endoscopy during pregnancy is associated with increased risk of preterm birth or small for gestational age, according to a study published in the February issue of Gastroenterology.

In vitro fertilization linked with increased risk of spontaneous preterm birth

November 8, 2017
A new analysis of published studies found an approximate 80% increased risk of spontaneous preterm birth (both before 37 and 34 weeks) when women become pregnant via in vitro fertilization (IVF) than through spontaneous conception.

Sleep-disordered breathing may affect pregnancy outcomes

July 8, 2014
(HealthDay)—Sleep-disordered breathing (SDB) may be associated with adverse pregnancy outcomes, according to research published in the June issue of the American Journal of Obstetrics & Gynecology.

Overall favorable outcomes for twin pregnancies in moms 45-plus

April 11, 2017
(HealthDay)—Twin pregnancies in older women (at least 45 years of age) overall have favorable outcomes but are associated with high rates of some complications, according to a study published in the May issue of Obstetrics ...

Recommended for you

Why mothers in mainland China, Hong Kong and Taiwan choose cesarean delivery

October 16, 2018
Pregnant women in mainland China, Hong Kong, and Taiwan are more likely to express preference for cesarean section (CS) as their mode of delivery later in pregnancy and postpartum, as compared to early in pregnancy, according ...

Importance of cell cycle and cellular senescence in the placenta discovered

October 15, 2018
Working with researchers from Stanford University and St. Anna Children's Cancer Research, researchers from Jürgen Pollheimer's laboratory at the Medical University of Vienna's Department of Obstetrics and Gynecology have ...

C-section rates have nearly doubled since 2000: study

October 12, 2018
(HealthDay)—The number of women delivering babies via cesarean section has nearly doubled worldwide since 2000, to about 21 percent, new research shows.

Study of nearly 41,000 women who almost died giving birth shows who's most at risk

October 10, 2018
Tens of thousands of American women each year need emergency treatment to save their lives while they deliver their babies, or immediately after. A new study shows how much their risk of a life-threatening birth depends on ...

In childbirth, when to begin pushing does not affect C-section rates

October 9, 2018
More than 3 million women in the United States give birth each year. But obstetricians have differing opinions about when women should begin pushing during labor and whether the timing of pushing increases the likelihood ...

Why single embryo transfer during IVF sometimes results in twins or triplets

October 8, 2018
It has been known for some time that it is better to transfer a single embryo to a woman's womb during assisted reproduction treatment (ART) rather than several embryos in order to avoid a multiple pregnancy and the risks ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.