Do prostate cancer cells have an Achilles' heel?

Do prostate cancer cells have an Achilles’ heel?
Credit: University of Illinois at Chicago

Researchers at the University of Illinois at Chicago describe new ways to selectively kill prostate cancer cells by exploiting the cells' revved-up metabolism. They report their findings in the online journal, eLife.

In prostate cancer, the loss of a called PTEN is very common. Without a functional copy of this gene, cancer is much more likely to develop. One of the downstream effects of the loss of PTEN is increased activation of an enzyme called protein kinase B, also known as Akt. Akt has multiple roles in the cell, including driving metabolism and cell proliferation—both of which are amped up in , contributing to their out-of-control growth and spread. Hyperactivation of Akt can also make cancer cells resistant to chemotherapy, but efforts to develop drugs to suppress Akt in cancer cells have fallen short due to toxicity.

The activation of Akt also produces elevated levels of , or ROS. These are byproducts of metabolism that can cause damage to cellular structures, including DNA.

Nissim Hay, professor of biochemistry and in the UIC College of Medicine, believes that these elevated ROS levels can be exploited to kill cancer cells.

"ROS levels are high in cancer cells, which normally helps them grow and proliferate," said Hay, who is a corresponding author on the paper together with UIC research assistant professor of biochemistry and molecular genetics Veronique Nogueira. "But, we have shown that by pushing ROS levels up above a certain threshold, they become toxic, and we can selectively kill off the cancer cells while leaving normal cells unharmed."

To boost ROS levels in cancer cells, Hay and colleagues suppressed ROS scavengers using a natural compound found in cruciferous vegetables, such as broccoli and cauliflower, called phenylethyl isothiocyanate, or PEITC.

In a mouse model of PTEN-deficient prostate cancer, PEITC, combined with a drug called rapamycin, almost completely eradicate tumors. Treated mice also showed no recurrence of cancer six months after the treatment stopped.

Next, the researchers targeted another downstream metabolic consequence of Akt hyperactivation: an enzyme called hexokinase 2, or HK2. They found that when they deleted the gene for HK2 in the mouse model of prostate cancer, the cancers in those mice stopped growing. The researchers saw similar results in human , where the deactivation of HK2 helped restore cell sensitivity to chemotherapy.

"The increased metabolism of cells presents a sort of Achilles' heel that we have several ways to exploit in order to very selectively kill these cells while are left alone," Hay said. More research is needed to determine how best to develop these findings into treatments, Hay explained.

More information: Veronique Nogueira et al. Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation, eLife (2018). DOI: 10.7554/eLife.32213

Journal information: eLife
Citation: Do prostate cancer cells have an Achilles' heel? (2018, April 25) retrieved 2 March 2024 from
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