Decellularized muscle grafts support skeletal muscle regeneration to treat tissue loss

May 4, 2018, Mary Ann Liebert, Inc
Credit: Mary Ann Liebert, Inc., publishers

A new comparative study showed the advantages of using donor decellularized muscle to promote functional tissue regeneration at the site of bulk skeletal muscle loss due to trauma or surgery. Compared to an autologous muscle graft, a decellularized muscle matrix used to repair medium- and large-sized defects in rats resulted in enhanced muscle function recovery, muscle regeneration, and the formation of new neuromuscular junctions, as reported in an article published in Tissue Engineering, Part A.

The article entitled "Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury" was coauthored by Barbara Boyan, PhD, Virginia Commonwealth University (VCU), Richmond and Georgia Institute of Technology, Atlanta and colleagues from VCU and Musculoskeletal Transplant. Foundation, Edison, NJ and University of Texas Health Science Center at San Antonio. The researchers demonstrated less scar tissue formation and more new neuromuscular receptors using a decellularized matrix than either a rat muscle autograft or collagen plugs to repair large muscle defects.

"This article demonstrated the potential of decellularized tissue grafts for use as scaffolds in engineering applications," says Tissue Engineering Co-Editor-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX.

Explore further: New approach to muscle regeneration restores function after traumatic injury without need for donor tissue

More information: Michael J. McClure et al, Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury, Tissue Engineering Part A (2018). DOI: 10.1089/ten.tea.2017.0386

Related Stories

New approach to muscle regeneration restores function after traumatic injury without need for donor tissue

April 16, 2015
Loss of muscle volume is a common and often debilitating outcome of traumatic orthopedic injury, resulting in muscle weakness and suboptimal limb function. A new therapeutic approach in which small pieces of autologous muscle ...

Keratin hydrogels show significant potential to regenerate lost muscle tissue and function

April 27, 2017
The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models ...

Scientists manipulate 'satellite cells' to speed healing

April 24, 2018
Muscle aches and pains, whether from stretching, strenuous exercise or just normal wear and tear, can put a crimp in your day, a limp in your step and be an actual pain in the neck. But no matter the severity, stem cells ...

Uncovering the genetics of skeletal muscle growth and regeneration

March 8, 2018
Skeletal muscle has a remarkable capacity to regenerate - a capacity that is diminished in many skeletal muscle diseases and aging. To investigate the mechanism behind skeletal muscle growth and regeneration, researchers ...

Muscle regeneration compromises stability in muscular dystrophy

March 1, 2018
A new study finds that muscle fibers in Duchenne muscular dystrophy (DMD) split during regeneration to such an extreme that the muscle is weakened beyond repair. The article is published ahead of print in the American Journal ...

From degeneration to regeneration: Advances in skeletal muscle engineering

November 26, 2012
A study published today in BioMed Central's open access journal Skeletal Muscle reports of a new therapeutic technique to repair and rebuild muscle for sufferers of degenerative muscle disorders. The therapy brings together ...

Recommended for you

Compound made inside human body stops viruses from replicating

June 20, 2018
The newest antiviral drugs could take advantage of a compound made not by humans, but inside them. A team of researchers has identified the mode of action of viperin, a naturally occurring enzyme in humans and other mammals ...

Research reveals zero proof probiotics can ease your anxiety

June 20, 2018
If you're expecting probiotics to reduce your anxiety, it might be time to put down that yogurt spoon—or supplement bottle—and call a professional instead.

Long-term estrogen therapy changes microbial activity in the gut, study finds

June 20, 2018
Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found.

Simple sugar delays neurodegeneration caused by enzyme deficiency

June 20, 2018
A new therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB (MPS IIIB). Neurodegeneration in this condition results from the abnormal accumulation of essential cellular ...

Researchers use AI to improve mammogram interpretation

June 20, 2018
In an effort to reduce errors in the analyses of diagnostic images by health professionals, a team of researchers from the Department of Energy's Oak Ridge National Laboratory has improved understanding of the cognitive processes ...

Everything big data claims to know about you could be wrong

June 19, 2018
When it comes to understanding what makes people tick—and get sick—medical science has long assumed that the bigger the sample of human subjects, the better. But new research led by UC Berkeley suggests this big-data ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.