Decellularized muscle grafts support skeletal muscle regeneration to treat tissue loss

May 4, 2018, Mary Ann Liebert, Inc
Credit: Mary Ann Liebert, Inc., publishers

A new comparative study showed the advantages of using donor decellularized muscle to promote functional tissue regeneration at the site of bulk skeletal muscle loss due to trauma or surgery. Compared to an autologous muscle graft, a decellularized muscle matrix used to repair medium- and large-sized defects in rats resulted in enhanced muscle function recovery, muscle regeneration, and the formation of new neuromuscular junctions, as reported in an article published in Tissue Engineering, Part A.

The article entitled "Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury" was coauthored by Barbara Boyan, PhD, Virginia Commonwealth University (VCU), Richmond and Georgia Institute of Technology, Atlanta and colleagues from VCU and Musculoskeletal Transplant. Foundation, Edison, NJ and University of Texas Health Science Center at San Antonio. The researchers demonstrated less scar tissue formation and more new neuromuscular receptors using a decellularized matrix than either a rat muscle autograft or collagen plugs to repair large muscle defects.

"This article demonstrated the potential of decellularized tissue grafts for use as scaffolds in engineering applications," says Tissue Engineering Co-Editor-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX.

Explore further: New approach to muscle regeneration restores function after traumatic injury without need for donor tissue

More information: Michael J. McClure et al, Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury, Tissue Engineering Part A (2018). DOI: 10.1089/ten.tea.2017.0386

Related Stories

New approach to muscle regeneration restores function after traumatic injury without need for donor tissue

April 16, 2015
Loss of muscle volume is a common and often debilitating outcome of traumatic orthopedic injury, resulting in muscle weakness and suboptimal limb function. A new therapeutic approach in which small pieces of autologous muscle ...

Keratin hydrogels show significant potential to regenerate lost muscle tissue and function

April 27, 2017
The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models ...

Scientists manipulate 'satellite cells' to speed healing

April 24, 2018
Muscle aches and pains, whether from stretching, strenuous exercise or just normal wear and tear, can put a crimp in your day, a limp in your step and be an actual pain in the neck. But no matter the severity, stem cells ...

Uncovering the genetics of skeletal muscle growth and regeneration

March 8, 2018
Skeletal muscle has a remarkable capacity to regenerate - a capacity that is diminished in many skeletal muscle diseases and aging. To investigate the mechanism behind skeletal muscle growth and regeneration, researchers ...

Muscle regeneration compromises stability in muscular dystrophy

March 1, 2018
A new study finds that muscle fibers in Duchenne muscular dystrophy (DMD) split during regeneration to such an extreme that the muscle is weakened beyond repair. The article is published ahead of print in the American Journal ...

From degeneration to regeneration: Advances in skeletal muscle engineering

November 26, 2012
A study published today in BioMed Central's open access journal Skeletal Muscle reports of a new therapeutic technique to repair and rebuild muscle for sufferers of degenerative muscle disorders. The therapy brings together ...

Recommended for you

Japanese team creates human oogonia using human stem cells in artificial mouse ovaries

September 21, 2018
A team of researchers with members from several institutions in Japan has successfully generated human oogonia inside of artificial mouse ovaries using human stem cells. In their paper published in the journal Science, the ...

A new approach to developing a vaccine against vivax malaria

September 21, 2018
A novel study reports an innovative approach for developing a vaccine against Plasmodium vivax, the most prevalent human malaria parasite outside sub-Saharan Africa. The study led by Hernando A. del Portillo and Carmen Fernandez-Becerra, ...

Researchers explore how changes in diet alter microbiome in artificial intestine

September 21, 2018
Using an artificial intestine they created, researchers have shown that the microbiome can quickly adapt from the bacterial equivalent of a typical western diet to one composed exclusively of dietary fats. That adaptation ...

A Trojan Horse delivery for treating a rare, potentially deadly, blood-clotting disorder

September 21, 2018
In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic ...

Study identifies stem cell that gives rise to new bone and cartilage in humans

September 20, 2018
A decade-long effort led by Stanford University School of Medicine scientists has been rewarded with the identification of the human skeletal stem cell.

Scientists grow human esophagus in lab

September 20, 2018
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.