Newly discovered anti-inflammatory substances may potentially treat variety of diseases

May 3, 2018, Bar-Ilan University

Researchers have discovered a new family of substances which has been found to display highly potent activity against the release of pro-inflammatory cytokines and the toxicity induced by reactive oxygen species (ROS). The novel compounds synthesized and evaluated belong to a family of low molecular weight substances named indolines. In early experiments, these compounds have shown promising activity in the treatment of acute pancreatic inflammation, acute fatty liver damage, and diabetes.

Inflammation, and in particular chronic , are major contributors to a large number of diseases, such as cancer, acute pancreatic inflammation, , diabetes, ulcerative colitis, Crohn's , rheumatoid arthritis, , atherosclerosis, multiple sclerosis, and many others. These pathological conditions are associated with the release of substances, known as pro-inflammatory cytokines, by the immune system. These substances participate in the neutralization of invading pathogens, repair injured tissues, and promote wound healing. However, during chronic or excessive activation of the immune system, when these cytokines are released in an uncontrolled manner, they can lead to unnecessary inflammation that frequently causes tissue damage.

In addition, a family of substances, designated as (ROS) is also among the major contributors to many chronic diseases. ROS are involved in oxidation processes. Although oxidative reactions catalyzed by ROS are of great importance in metabolic processes and removal of toxic substances from the body, they are also involved in major damage to cells and tissues leading to cell death, possible DNA mutations and aging. Though the presence of oxygen is necessary for maintaining life, oxygen and its derived products (ROS) are involved in a variety of toxic effects. It has been said that "without oxygen we die but kills us".

Prof. Abraham Nudelman and his graduate student Shani Zeeli, from the Department of Chemistry at Bar-Ilan University, in collaboration with Prof. Marta Weinstock and her students and assistants from the School of Pharmacy at the Hebrew University, have discovered a new family of substances which has been found to display highly potent activity against the release of pro-inflammatory cytokines and the toxicity induced by ROS. Their findings were recently published in the Journal of Medicinal Chemistry, and in other early papers.

The novel compounds synthesized and evaluated belong to a family of low molecular weight substances named indolines. In early experiments, these compounds have shown promising activity in the treatment of acute pancreatic inflammation, acute fatty liver damage, and diabetes.

"It is expected that further studies in humans will reveal the potential usefulness of these in the treatment of a variety of diseases where inflammation is a major contributor to the disease," says Prof. Nudelman, a lead author of the paper. Further studies on the influence of these compounds on these diseases, and other pathological conditions, are being conducted.

Explore further: Researchers report inflammation suppression process

More information: Shani Zeeli et al, Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents, Journal of Medicinal Chemistry (2018). DOI: 10.1021/acs.jmedchem.8b00001

Related Stories

Researchers report inflammation suppression process

February 23, 2018
Inflammation needs energy An important source for this energy is oxygen, which is indispensable for the cells of the immune system to work properly. Oxygen is an essential element required for cells to survive, but it also ...

Searching for targeted treatments for inflammatory diseases

February 6, 2018
Inflammatory diseases such as Crohn's disease and multiple sclerosis have been linked to faults in a critical immune pathway that enables inflammation to continue unchecked.

Fatty liver can cause damage to other organs via crosstalk

August 21, 2017
Nonalcoholic fatty liver disease is increasingly common. Approximately every third adult in industrialized countries has a morbidly fatty liver. This not only increases the risk of chronic liver diseases such as liver cirrhosis ...

Stem cells may significantly improve tendon healing by regulating inflammation

May 23, 2017
New research published online in The FASEB Journal suggests that tendon stem (TSCs) may be able to significantly improve tendon healing by regulating inflammation, which contributes to scar-like tendon healing and chronic ...

Lower levels of antioxidants may lessen damage from colitis

September 29, 2017
A new study finds that lowering the levels of an antioxidant in the colon has an unexpectedly positive effect on gastrointestinal (GI) inflammation. The paper is published ahead of print in the American Journal of Physiology—Gastrointestinal ...

Recommended for you

Chance discovery links inflammatory bowel disease with common bacterial gut toxin

May 17, 2018
New research has uncovered a surprise link between a common bacterial toxin found in the gut and inflammatory bowel disease (IBD).

New cytokine network can repair tissue damage in the intestine, study finds

May 16, 2018
A new group of proteins called cytokines, critical for antimicrobial activity and repairing the damaged intestinal tissue found in inflammatory bowel disease (IBD), has been discovered by researchers in a study led by Georgia ...

International study suggests alternative treatment for mild asthma

May 16, 2018
A large international study led by a Hamilton researcher has found a patient-centric treatment that works for people with mild asthma.

Study shows yogurt may dampen chronic inflammation linked to multiple diseases

May 14, 2018
Inflammation can be good. It's part of the body's innate immune system, our first line of defense against illness and injury.

New study provides insight into blood signatures of inflammation

May 8, 2018
A new study from Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) identifies a pattern of inflammation associated with cardio-metabolic risks among participants in the Black Women's Health Study, as ...

Metabolites shed by intestinal microbiota keep inflammation at bay

May 4, 2018
Researchers at Tufts University have elucidated a mechanism by which the "good" bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.