Mouse memory cells are about experience, not place

The big picture: Mouse memory cells are about experience, not place
Credit: RIKEN National Science Institute and Milena Carvalho

When it comes to memory, it's more than just "location, location, location." New research suggests that the brain doesn't store all memories in place cells, the main type of neuron in the hippocampus, a structure crucial for navigation and memory. Instead, memories seem to be powered by a subset of hippocampal cells that have little to do with location and more with context or episodes, as reported in the July 27 issue of Science.

The is well-known as the domain of place cells, whose discovery and function as mental maps of space was recognized with the 2014 Nobel Prize in Physiology or Medicine. On the other hand, as a hotspot for research, the hippocampus is proposed as the physical for memories of experiences, stored in engram cells. "Neuroscience is still grappling with the engram memory concept," says research group leader Thomas McHugh of the RIKEN Center for Brain Science in Japan. "We know what these cells do when they're activated, but what do they represent, and how do they function?"

The assumption is that memory engrams are just place cells, but McHugh's group thinks they have an alternative explanation. In their experiments, mice spent time in one kind of cage to make a memory of that environment. The researchers used optogenetic methods to identify the cells that were active during that time and therefore contributed to the memory. These cells represented only a fraction of hippocampal place cells and had larger place fields—the corresponding real-world area that gets the cell excited when the mouse is exploring. Analysis of the activity across a large number of cells revealed that, while most place cells kept the same spatial map during both the initial and later visit to the cage, the engram cells had uncorrelated activity between the two time points. The only exception was very early during both visits when the cells' activity was similar, which is what you would expect if they are involved in the recall of context.

When the mice were placed in a second, different cage, the engram cells remained inactive—they were already 'occupied' with the previous memory. In fact, the researchers were able to tell the first and second environments apart just by comparing the activity of these cells. The engram cells are only active for the memory of the context itself, not to specific locations, while place cells, on the other hand, are active during exploration, creating and updating a spatial map. Recognizing a context or environment doesn't require walking through or exploring, so location cells thus appear to be distinct from .

The instability of the spatial information signaled by engram cells compared with the majority of indicates that they deal with the big picture, the macro-scale of a context, and not a specific location therein. The researchers propose that engram may not store memories per se, but to act as an index that ties memory-relevant details together, wherever else in the brain those may be. "Their role is to track elements of a memory, whether those are from sound or vision or other senses, and then trigger their recall by activating other parts of the brain like the cortex," McHugh hypothesizes. While the hippocampus clearly does underlie spatial memory, this newly revealed function as an index for contextual identity shows that this brain region is about more than just maps. "We long assumed memory is anchored to stable representations of locations," says McHugh, "but it's actually the opposite."


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More information: K.Z. Tanaka el al., "The hippocampal engram maps experience but not place," Science (2018). science.sciencemag.org/cgi/doi … 1126/science.aat5397
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Jul 27, 2018
[P1] It is interesting to note that one of the main memory classification methods is apparently ignored in current memory research, that of 'Episodic', 'Semantic' and 'Procedural' memory. That scheme, amazingly and for no apparent reason, left out 'Orientation' for which you would need 'Place Cells', so I suppose this is some kind of academic payback for being ignored?

It is interesting to note that when a person's consciousness is in question, such as when they have suffered a possible concussion, doctors query Orientation memory eg 'Where are you?', 'What day is it?' and so on, questions relating to a person's orientation in space, time and in their culture....

Jul 27, 2018
P2] Each of the four memory types have a different function with regard to the way they updated and changed through time and the same information can be stored in multiple memory systems. For instance, using the old bike riding example for procedural memory, you can learn all the steps to riding a bike intellectually without ever seeing a bike or riding one. This would not have entered procedural memory for which actually riding the bike is a necessary activity. You can recall each episode in which you rode a bike as a child even if you have lost the skill (procedural memory) of riding it. And you can know the word 'bike' and its relation to other words, the category in which the word belongs and the words that belong to the same category (Semantic memory). And of course the memory of where you can ride the bike and what you will find along the way is a function of orientation memory which will be aided by the now well known place cells.

Jul 27, 2018
P3] I would say that knowledge for knowledge's sake is a function of semantic memory. I'd also note that each of the memory systems can have some kind of role in each kind of memory event so even listening to music with your eyes closed will evoke Orientation memory and Procedural memory can have you up and dancing!! I also assume that there is a short term store for each kind of memory function. The only memory theory or model that we can rule out arbitrarily is the one/s that assume that there is only one kind of memory and only one kind of memory system, unfortunately the misguided hunt for a single explanation or model for cognitive activity is a dream of academics in many fields, cooperation in this area not being a priority as they strive to annex intellectual territory for their own discipline, model or approach.

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