Routine genomic screening could find risks for cancer and heart disease in 3 to 4 million unsuspecting Americans

July 31, 2018, American College of Physicians

Unbeknownst to them, at least 1 percent of the U.S. population has an identifiable genetic risk for cancer or heart disease that could be detected and clinically managed through genomic screening. The author of an article published in Annals of Internal Medicine says that identifying those 3 to 4 million persons and effectively mitigating that risk are worthy goals, but more work is needed before genomic screening becomes routine in health care.

According to the author from Yale School of Medicine, current implementation models that demonstrate the clinical utility of routine genomic screening are still preliminary, but show promising results. While the majority of people who receive genomic screening would not find anything that would prompt significant changes to current medical management, the benefit to the few who do have a meaningful finding could be significant. Early case reports show that this approach can identify subclinical disease and prompt important medical interventions.

Cohesive models for implementing genomic in routine care are lacking and opportunities to advance knowledge of clinical utility are being missed, according to the author. If achieving better health is the goal, then functioning implementation models must be developed.

Explore further: Prediction tool helps tailor lung cancer screening to patients

More information: Annals of Internal Medicine (2018). http://annals.org/aim/article/doi/10.7326/M18-1722

Related Stories

Prediction tool helps tailor lung cancer screening to patients

May 30, 2018
(HealthDay)—Personalizing the harm-benefit assessment of low-dose computed tomography (LDCT) screening for lung cancer can inform patient-centered screening decisions, according to a study published online May 29 in the ...

Researchers identify the most accurate risk prediction models for selecting whom to screen for lung cancer

May 15, 2018
Four risk prediction models have been shown to be most accurate for selecting the highest risk ever-smokers for lung cancer screening. Researchers suggest that this data can be used to inform future lung cancer screening ...

Electronic health record alert improves HCV screening and treatment among baby boomers

September 15, 2017
In a recent study, screening rates for hepatitis C virus (HCV) infection among baby boomers increased fivefold in the year following implementation of an electronic health record (EHR)-based prompt for primary care physicians. ...

PSA screening significantly reduces the risk for death from prostate cancer

September 5, 2017
After differences in implementation and settings were accounted for, two important prostate cancer screening trials provide compatible evidence that screening reduces prostate cancer mortality. These findings suggest that ...

EHR-based prompt ups hepatitis C screening for baby boomers

July 20, 2017
(HealthDay)—Implementation of an electronic health record (EHR)-based prompt can improve hepatitis C virus (HCV) screening rates among baby boomers, according to a study published online July 17 in Hepatology.

Patient with CAS of 50 percent should not undergo screening

October 3, 2017
(HealthDay)—A vascular surgeon and primary care physician agree that an asymptomatic patient with cardiovascular risk and stenosis of 50 percent on screening carotid ultrasonography should not undergo carotid artery stenosis ...

Recommended for you

Pregnant? Eating broccoli sprouts may reduce child's chances of breast cancer later in life

August 16, 2018
Researchers at the University of Alabama at Birmingham have found that a plant-based diet is more effective in preventing breast cancer later in life for the child if the mother consumed broccoli while pregnant. The 2018 ...

Three scientists share $500,000 prize for work on cancer therapy

August 15, 2018
Tumors once considered untreatable have disappeared and people previously given months to live are surviving for decades thanks to new therapies emerging from the work of three scientists chosen to receive a $500,000 medical ...

PARP inhibitor improves progression-free survival in patients with advanced breast cancers

August 15, 2018
In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over ...

New clues into how 'trash bag of the cell' traps and seals off waste

August 15, 2018
The mechanics behind how an important process within the cell traps material before recycling it has puzzled scientists for years. But Penn State researchers have gained new insight into how this process seals off waste, ...

RUNX proteins act as regulators in DNA repair, study finds

August 15, 2018
A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) ...

Chemicals found in vegetables prevent colon cancer in mice

August 14, 2018
Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study from the Francis Crick Institute shows.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.