Unfavorable prepregnancy lipid levels linked to low parity
Aleksandra Pirnat, from the University of Bergen in Norway, and colleagues conducted a prospective, population-based cohort study using data for 2,645 women giving birth to their first child during 1994 to 2003 (488 one-child mothers and 2,157 women with two or more births) and 1,677 nulliparous women.
The researchers observed an association for higher prepregnancy triglyceride (TG) and TG to high-density lipoprotein cholesterol (TG:HDL-c) ratio levels with increased risk of one lifetime pregnancy, compared with having two or more children. The risk of one lifetime pregnancy was increased for women in the lowest versus the highest quintile of HDL-c levels (odds ratio, 1.7; 95 percent confidence interval, 1.2 to 2.4) and for women with the highest versus the lowest low-density lipoprotein (LDL) cholesterol, TG, and TG:HDL-c ratio quintiles (odds ratios, 1.2 [95 percent confidence interval, 0.8 to 1.7]; 2.2 [95 percent confidence interval, 1.5 to 3.2]; and 2.2 [95 percent confidence interval, 1.5 to 3.2], respectively). Women with a body mass index ≥25 kg/m² and the highest LDL and total cholesterol levels had similar effects in risk of lifetime nulliparity.
"These findings substantiate an association between prepregnant serum lipid levels and number of children," the authors write.
Copyright © 2018 HealthDay. All rights reserved.