Microneedle patch shows promise as a means for repairing muscle after heart attack

November 29, 2018 by Bob Yirka, Medical Xpress report
A cardiac cell-integrated microneedle patch (blue) on an injured heart for repair. Credit: Ke Cheng/Zhen Gu

A team of researchers has found that applying a specially designed microneedle patch could benefit damaged heart after heart attack. In their paper published in the journal Science Advances, the group explains the related mechanics of the patch and how well it worked when tested on animals.

During a heart attack, blood often stops flowing to certain parts of the cardiac muscle, leading to cell death and damage to the heart. In most cases, this kind of damage would leave patients with reduced cardiac function. In recent years, scientists have been trying to apply stem cells to damaged heart tissue to heal it-but such research has not progressed well. In this new effort, the researchers applied an integrated microneedle patch to the damaged area to introduce the paracrine effect by the stromal cells and allow cardiac function protection. The patch works by means of micro channels opened by microneedles, which direct the therapeutic substance secreted by stromal cells to heart cells and promote the communication. The patch is called MN-CSC.

The new technique involves cutting open the chest to gain access to the damaged area in animal model. Next, a microneedle patch is applied directly to the damage. The chest is then sewn back together and the animal is taken care to recover. The researchers have tested the patch on rats and pigs. They report that it reduced cell death and also promoted the growth of myocytes and vasculatures, which contributed to the cardiac protection.

The researchers note that the patch is biocompatible and works as expected. The next step is, they plan to explore ways to apply a patch that do not involve open heart surgery.

Explore further: Stem cell patch shows early promise in treating heart failure

More information: Junnan Tang et al. Cardiac cell–integrated microneedle patch for treating myocardial infarction, Science Advances (2018). DOI: 10.1126/sciadv.aat9365

Related Stories

Stem cell patch shows early promise in treating heart failure

April 5, 2017
Patching a damaged heart with a patient's own muscle stem cells improves symptoms of heart failure, according to a Phase I clinical trial reported in Journal of the American Heart Association, the Open Access Journal of the ...

Regenerating heart muscle tissue using a 3D printer

September 14, 2017
The combination of the Canadian Light Source (CLS) synchrotron's unique biomedical imaging and therapy (BMIT) beamline and the vision of a multi-discipline researcher from the University of Saskatchewan in confirming fiction ...

Stem cell-sheet transplantation feasible in cardiomyopathy

April 6, 2017
(HealthDay)—Stem cell-sheet transplantation shows promise in the treatment of cardiomyopathy, according to research published online April 5 in the Journal of the American Heart Association.

3-D-printed patch can help mend a 'broken' heart

April 14, 2017
A team of biomedical engineering researchers, led by the University of Minnesota, has created a revolutionary 3D-bioprinted patch that can help heal scarred heart tissue after a heart attack. The discovery is a major step ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

Injectable tissue patch could help repair damaged organs

August 14, 2017
A team of U of T Engineering researchers is mending broken hearts with an expanding tissue bandage a little smaller than a postage stamp.

Recommended for you

Can stem cells help a diseased heart heal itself? Researchers achieve important milestone

December 14, 2018
A team of Rutgers scientists, including Leonard Lee and Shaohua Li, have taken an important step toward the goal of making diseased hearts heal themselves—a new model that would reduce the need for bypass surgery, heart ...

Law professor suggests a way to validate and integrate deep learning medical systems

December 13, 2018
University of Michigan professor W. Nicholson Price, who also has affiliations with Harvard Law School and the University of Copenhagen Faculty of Law, suggests in a Focus piece published in Science Translational Medicine, ...

Exercise-induced hormone irisin triggers bone remodeling in mice

December 13, 2018
Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling ...

Faster test for Ebola shows promising results in field trials

December 13, 2018
A team of researchers with members from the U.S., Senegal and Guinea, in cooperation with Becton, Dickinson and Company (BD), has developed a faster test for the Ebola virus than those currently in use. In their paper published ...

Drug targets for Ebola, Dengue, and Zika viruses found in lab study

December 13, 2018
No drugs are currently available to treat Ebola, Dengue, or Zika viruses, which infect millions of people every year and result in severe illness, birth defects, and even death. New research from the Gladstone Institutes ...

Pain: Perception and motor impulses arise in brain independently of one another

December 13, 2018
Pain is a negative sensation that we want to get rid of as soon as possible. In order to protect our bodies, we react by withdrawing the hand from heat, for example. This action is usually understood as the consequence of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.