Dopamine conducts prefrontal cortex ensembles

dopamine
Ball-and-stick model of the dopamine molecule, a neurotransmitter that affects the brain's reward and pleasure centers. Credit: Jynto/Wikipedia

Anyone who has savored a bite of chocolate or glanced at each new blinking notification on their smart phone is familiar with dopamine.

But that is not all does. This chemical neurotransmitter also plays a fundamental role in the prefrontal of the brain, which controls higher functions such as paying attention, staying motivated, and making decisions.

Now, research in rodents reveals for the first time how dopamine changes the function of the prefrontal cortex. In a study published in the journal Cell Reports, researchers found that dopamine has little effect on . Instead, it generates sustained activity in the ensemble of cells in the prefrontal cortex that lasts for up to 20 minutes.

"Ensemble brain cell activity, just like ensembles of musicians who perform together, can have a different and greater effect than the activity of individual neurons" said senior author Bita Moghaddam, Ph.D., professor and chair of behavioral neuroscience in the OHSU School of Medicine.

The coordinated ensemble activity initiated by dopamine lasted for many minutes after it was released.

"This may provide a mechanism by which dopamine supports complex functions that have to be sustained, such as motivation and attention to complete a task," Moghaddam said.

Using optogenetic methods in the brains of rodents during active behavior, researchers stimulated dopamine neurons in the brain with light and then recorded the response in the prefrontal cortex. They detected a relatively weak signal among individual cells. However, a computational method of analysis discerned multiple forms of coordinated activity among cells in the prefrontal cortex that lasted several minutes following the initial burst of light.

In addition to the impact of dopamine on the ensemble activity, the study demonstrated that dopamine increase oscillatory activity, or brain waves, at the gamma range. Disruptions in brain oscillation at this high frequency had been previously linked to attention, as well disorders such as schizophrenia and ADHD, but the cause of this disruption is not well understood.

The discovery of dopamine's role provides fresh insight into a key mechanism in the brain. Dopamine in the of the brain plays a role in almost all aspects of high order cognition, including attention and behavioral flexibility. It's also implicated in motivational and cognitive deficits of illnesses such as schizophrenia, addiction and attention-deficit/.

"This could explain why you need dopamine for sustained ," Moghaddam said. "It can help us understand how in disorders like ADHD, where there could be a dopamine deficit, that the impact may not be at individual neuron but the ensemble level."


Explore further

Amphetamine abuse disrupts development of mouse prefrontal cortex

More information: Cell Reports (2019). DOI: 10.1016/j.celrep.2019.03.012
Journal information: Cell Reports

Citation: Dopamine conducts prefrontal cortex ensembles (2019, April 2) retrieved 22 October 2019 from https://medicalxpress.com/news/2019-04-dopamine-prefrontal-cortex-ensembles.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
137 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more