Discovery could improve MDS cancer treatment

Discovery could improve MDS cancer treatment
Immature blood cells (stained purple) do not divide into enough functioning red blood cells when defective. Researchers have discovered how to stop the protein signaling pathway that makes this defect so dangerous. Credit: Zhang lab/CSHL, 2019

Myelodysplastic syndrome (MDS), one of the most common blood cancers, has very few treatment options. Now, researchers at Cold Spring Harbor Laboratory (CSHL) have discovered a new and promising drug target for this deadly condition.

"At the moment, only a small portion of patients benefit from the standard therapy for MDS," said CSHL Fellow and cancer researcher Lingbo Zhang. "Therefore, there is a very important medical need for a new and novel therapy for this disease."

Zhang's lab working with experts from Memorial Sloan Kettering Cancer Center and National Institute of Diabetes and Digestive and Kidney Diseases discovered the new drug target that could meet this need. Their research was recently published in Science Translational Medicine.

"We have been working with a multidisciplinary team that consists of physicians and medicinal chemists to translate our basic discovery into novel therapeutics which can be tested in for the benefit of patients," Zhang said.

The ultimate goal, Zhang said, is to create a drug that will adequately restore blood cell production in MDS patients who are resistant to existing treatments.

To understand exactly how the new drug target works, it's important to first know why MDS is so difficult to treat. Unlike many other cancers, MDS is not characterized by a tumor. Instead, this is sometimes referred to as "bone marrow failure disorder."

Bone marrow is designed to produce enough blood for everyday survival. When are lost via bleeding or when they grow too old to do their job, replacement are made and begin to mature. MDS results from those replacements being too few, defective or both.

Traditional treatment options for MDS symptoms, such as anemia, rely on the body's natural ability to make more mature red blood cells, which is driven by a hormone called erythropoietin (EPO).

Immature red blood cells developing in the bone marrow, called progenitor cells, must be exposed to EPO to trigger their final change into fully mature red blood cells ready to aid the body. It would then stand to reason that delivering lots of EPO to the bone marrow would fix most MDS cases. But this is simply not the case.

The reason that only a small portion of patients respond to common EPO-based treatments is because many MDS patients don't have enough functional progenitor cells within their bone marrow to begin with. In some cases, what functional cells are available will indeed become mature red blood cells. However, once that supply runs out, EPO treatments stop working, causing drug resistance. That's why Zhang and his colleagues decided to take a different approach.

"So to treat this," Zhang explained, "you can't target the late progenitor. Their capacity to make new cells is very limited. But with the earlier cells, we have a chance."

Instead of relying on EPO and its target progenitor cells, they chose to target an even younger stage of the progenitor cells. The researchers discovered that when these cells are defective, activating a specific protein receptor called CHRM4 significantly hampers their ability to divide into those crucial EPO-responsive . By blocking this receptor, Zhang and his colleagues could restore healthy cell production.

In mice genetically designed to mirror the pathological features of human MDS, this strategy significantly improved survival rates.

"More importantly, these preclinical tests have shown that the treatment exhibited a sustained and long-term therapeutic efficacy," Zhang said. "We're now translating this discovery into clinical development, and we hope our progress will benefit patients in the near-future."

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More information: G. Trivedi el al., "Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors," Science Translational Medicine (2019). … scitranslmed.aaw3781
Journal information: Science Translational Medicine

Citation: Discovery could improve MDS cancer treatment (2019, September 25) retrieved 15 August 2020 from
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