The importance of individualized models for understanding brain function

The importance of individualized models for understanding brain function
A) An illustration of a hybrid SC. The connections between all areas are extracted from dMRI data (red nodes and links) except for the connections of a single area, which are obtained from the Allen SC (green). The graph shows the difference in PP between hybrid and individual deterministic dMRI SCs. The change in PP is calculated as the difference between the PP of the hybrid SC and the individual dMRI SC averaged across all sessions and animals. P values refer to the t test for the null hypothesis that substituting the tracer connections of a given brain region in the dMRI connectome does not change the PP of the connectome. Nomenclature and abbreviations are listed in SI Appendix, Table S1. (B) Comparison between the PP of tracer-based and hybrid SCs revealed that connectomes (hybrid best), which were generated by replacing the connection of a single area in each mouse, predict experimental FC better than the filtered and symmetrized connectomes (filtered & Sym). Welch’s test, Bonferroni corrected, **P < 0.01, ***P < 0.001, ****P < 0.0001; n.s., nonsignificant. (C) Comparison between the change in PP following hybridization of left and right brain areas reveals that replacement of left area connections decreased the PP more than right area connections (paired t test). (D) The differences in PP between right and left hybrid SCs were correlated with the lateralization of experimental FC, which was quantified as the Euclidean distance between left and right functional connections. The closer the lateralization index is to 1, the more similar are the intrahemispheric left and right area connections. Different colors label different mice. Credit: Proceedings of the National Academy of Sciences

New research conducted by Professor Itamar Kahn, director of the Brain Systems Organization in Health and Disease Lab in the Technion's Rappaport Faculty of Medicine, in collaboration with scientists from France and the U.S., demonstrates the importance of personalized brain models. The research team's findings show that individual variations in the brain's structural connectome (map of neural connections) define a specific structural fingerprint with a direct impact on the functional organization of individual brains.

The groundbreaking research, "Individual structural features constrain the mouse functional connectome," was published in PNAS, the official journal of the National Academy of Sciences of the United States. Technion MD/Ph.D. candidate Eyal Bergmann and Université d'Aix-Marseille doctoral student Francesca Melozzi were lead co-authors.

By using a connectome-based model approach, Prof. Kahn and his partners aimed to understand the functional organization of the brain by modeling the brain as a dynamic system, then studying how the functional architecture rises from the underlying structural skeleton. Taking advantage of studies, they systematically investigated the informative content of different structural features in explaining the emergence of the functional ones.

Whole brain dynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional is unknown, even though its importance is uncontested. After acquiring structural MRI data from individual mice, the researchers virtualized their brain networks and simulated in silicofunctional MRI data. Theoretical results were validated against empirical awake functional MRI data obtained from the same mice. As a result, the researchers were able to demonstrate that individual structural connectomes predict the functional organization of individual brains.

While structural MRI is a common non-invasive method that can estimate structural connectivity in individual humans and rodents, it is not as precise as the gold standard connectivity mapping possible in the mouse. Utilizing precise mapping available in mice, the authors identified which missing connections (not measurable with structural MRI) are important for whole dynamics in the . The researchers identified that individual variations thus define a specific structural fingerprint with a direct impact upon the functional organization of individual brains, a key feature for personalized medicine.

More information: Francesca Melozzi et al. Individual structural features constrain the mouse functional connectome, Proceedings of the National Academy of Sciences (2019). DOI: 10.1073/pnas.1906694116
Citation: The importance of individualized models for understanding brain function (2020, January 3) retrieved 7 December 2022 from
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