Genomic adaptations to a rice-based diet mitigate the risk of obesity and diabetes

Genomic adaptations to a rice-based diet mitigate the risk of obesity and diabetes
Blue clusters showed predominant South Asian ancestry, while red ones are enriched for East and South East Asian ancestry. Red concentric circles indicate archaeological sites along the Yangtze River valley in Eastern China where remains suggesting usual consumption of wild rice have been dated to at least 12,000 years ago. Green concentric circles indicate archaeological sites in the Hebei and Manchuria provinces of Northern China where remains suggesting early cultivation of broomcorn millet and foxtail millet were found. Conversely, all the remaining clusters were used as control groups (i.e., populations not expected to have evolved adaptations to cereal?based diets despite using rice as a staple food). Blue concentric circles indicate archaeological sites across the Indo-Gangetic Plain where evidence for more recent domestication of O. sativa indica was found. Credit: Evolutionary Applications

The traditional rice-based diet of some east-Asian population has brought a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity. An international study led by the University of Bologna and published in the journal Evolutionary Applications has recently suggested this interesting hypothesis. Researchers analyzed and compared the genomes of more than 2,000 subjects from 124 south-east-Asian populations.

"We suggest that it may be possible that some east-Asian populations, whose ancestors started eating on a daily basis at least 10,000 years ago, have evolved genomic adaptations that mitigate the harmful effects of high-glycaemic diets on metabolism," confirms Marco Sazzini, study coordinator and professor at the Department of Biology, Geology and Environmental Sciences of the University of Bologna. "Furthermore, these adaptations plausibly continue to play a pivotal role in protecting them from the negative effects that derive from major dietary alterations brought about by the globalization and westernization of their lifestyles. These alterations dramatically increased their consumption of food rich in processed sugar and with a high glycaemic index."

Rice And Glycemic Index

Among the so-called domesticated cereals, rice presents a high glycaemic index and is rich in carbohydrates. This means that once ingested and digested, it causes sugar in the blood to increase. If eaten regularly and in large quantities, rice may represent a potential risk factor for developing insulin resistance and related metabolic diseases such as type 2 diabetes.

However, if we compare east-Asian people having used rice as a staple food for over 10,000 years with those in the Indian sub-continent, we soon find out that the latter show higher rates of diabetes and obesity than east-Asians. Why are these two groups different?

A 10,000-Year-Old Diet

Archaeology may provide a hint to answering that question. Archaeobotanical findings in some eastern regions of Asia show that wild rice had been part of the inhabitants' diets in the past starting 12,000 years ago. After rice domestication and the introduction of rice farming techniques, between 7,000 and 6,000 years ago, rice spread rapidly across Korea and Japan. In northern regions of the Indian sub-continent, an independent domestication process had started 4,000 years ago and brought to the selection of rice varieties presenting a lower glycaemic index if compared to east-Asian rice.

"Different rice varieties and a head start of millennia may have put populations in China, Korea, and Japan under a more pressing metabolic stress than that experienced by south Asian populations," explains Arianna Landini, first author of this study and a Ph.D. student at the University of Edinburgh. "This might have allowed them to evolve genomic adaptations that mitigate the risk of becoming ill with metabolic diseases linked with a high-sugar diet."

Rice And Genomic Adaptations

To test such a hypothesis, researchers analyzed the genome of more than 2,000 subjects from 124 east-Asian and south-Asian populations. Then, they compared the adaptive evolution observed in Chinese Han and Tujia , as well as in people of Korean and Japanese ancestry (with a long-standing tradition of rice-based diets) with that of people from regions of Pakistan, Bangladesh, Myanmar, Vietnam, and south-east Asia. Southeast Asian subjects were used as control groups because their adoption of cereal-based diets occurred many thousand years later.

"The genomic adaptations observed in control groups differ greatly from those of east Asian populations and are not related to metabolic stress due to a specific diet," says Claudia Ojeda-Granados, one of the authors and a research fellow at the University of Bologna. "Chinese Han and Tujia ethnic groups, as well as people of Korean and Japanese ancestry show instead similar metabolic genomic adaptations."

Some of the the researchers identified are associated with a lower BMI and a weaker risk of cardiovascular diseases thanks to a reduced conversion of carbohydrates into cholesterol and fatty acids. Some other adaptations favor a reduced insulin resistance as they negatively modulate the glucogenesis in the liver. Finally, some others stimulate the production of retinoic acid, which is a metabolite of vitamin A. Deficiency in this nutritional organic compound often causes health-issues in people eating a rice-based .

"Our results demonstrate once again how studying evolutionary history may successfully inform biomedical research, eventually leading to the identification of the mechanisms underlying the different susceptibility of human populations to different diseases," concludes Sazzini.

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More information: Arianna Landini et al, Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry, Evolutionary Applications (2020). DOI: 10.1111/eva.13090
Provided by Università di Bologna
Citation: Genomic adaptations to a rice-based diet mitigate the risk of obesity and diabetes (2020, September 21) retrieved 20 October 2020 from
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