Pregnancy stress may shape baby brain

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Stress levels in mothers—measured by a hormone linked to anxiety and other health problems—is related to changes in areas of the infant brain associated with emotional development, the study suggests.

Doctors say the findings highlight the urgent need for women to be better supported with their mental and physical health before and during pregnancy, and could help them spot mums and who need help.


The experts add that pregnant women who feel stressed or unwell should seek help from their midwife or consultant and that with support, most health issues can be well managed in pregnancy.

Maternal stress is known to influence the development of the child's behavior and ability to regulate its emotions as it grows.

This is usually measured by questionnaires, which are not always reliable.

Cortisol levels

The new study is the first time that scientists have used an objective measure—levels of the hormone cortisol—in the mother to study links with baby development.

Cortisol is involved in the body's response to stress—with higher levels indicating higher stress—and also plays a role in fetal growth.

A research team led by the University of Edinburgh showed that levels of cortisol are linked to the development of the baby's amygdala, an area of the brain known to be involved in emotional and social development in childhood.

For the study, scientists took hair samples from 78 pregnant women to determine the women's levels of cortisol in the previous three months.

Brain scanning

The women's babies underwent a series of brain scans using Magnetic Resonance Imaging, or MRI, a non-invasive scan that took place whilst the baby slept.

The researchers found that higher levels of cortisol in the mother's hair were linked to structural changes in the infants' amygdala as well as differences in brain connections.

Doctors say this could explain why children whose mothers experienced high levels of stress during pregnancy may be more likely to have emotional issues in later life. They caution, however, that the study did not assess emotion in children.

The study was funded by the global children's charity, Theirworld, and is published in the journal eLife.

"Our findings are a call to action to detect and support who need extra help during pregnancy as this could be an effective way of promoting healthy brain development in their babies," says Professor James Boardman.

"Thankfully, are very successful at helping mothers and children and we hope that our findings could guide therapies in future to help spot those who might be most in need of support," says Professor Rebecca Reynolds.

"This research highlights how important it is to support women's mental health during pregnancy to ensure that their needs are met and that their babies have the best start in life. Helping mothers cope with stress is an important step to ensure both mum and baby thrive," says Sarah Brown, chair of Theirworld.

More information: David Q Stoye et al. Maternal cortisol is associated with neonatal amygdala microstructure and connectivity in a sexually dimorphic manner, eLife (2020). DOI: 10.7554/eLife.60729

Journal information: eLife

Citation: Pregnancy stress may shape baby brain (2020, November 24) retrieved 8 June 2023 from
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