Little-known glial cells regulate development and function of the heart

Little-known glial cells regulate development and function of the heart
A section of heart tissue that reveals the nexus glia of the heart (green) interact with neurons (blue) and heart cells (red), likely to modulate heart function. Credit: Nina Kikel-Coury, CC BY 4.0 (

Glial cells in the heart help regulate heart rate and rhythm, and drive its development in the embryo, according to a new study publishing November 18th in the open-access journal PLOS Biology by Nina Kikel-Coury, Cody Smith and colleagues at the University of Notre Dame. The discovery provides the most detailed portrait yet of a critical population of cells that had been previously poorly understood.

Glia are a diverse set of cell types, originally named after the Greek word for glue, and include cells that surround and nourish neurons, and others that mount immune responses within the . In the , glia are present and presumably active in multiple organs, including the gut, pancreas, spleen, and lungs, although their function is not clear in most cases.

Recently, a in the heart that expresses a known astroglial marker has been reported, and a part of the developing heart called the includes a group of cells derived from an embryonic structure called the , which is the source of most peripheral .

These intriguing clues led the authors to look more deeply at the identity and function of these cells. Beginning in zebrafish, they found an abundant group of cells in the heart's ventricles that produced glial fibrillary acid protein (GFAP), a classic marker of glia. GFAP-positive cells were also found in the hearts of mice and humans. Those cells were concentrated in the so-called outflow tract in , a structure that forms in the heart during development and contributes to the pathway that connects the ventricles to the arteries leaving the heart. Killing these cells increased the rate of nerve development in the embryonic heart, suggesting they play an inhibitory or delaying role in cardiac innervation. By a variety of methods, including tracking individually labeled cells as they migrated, the researchers showed that the glial cells that take up residence in the outflow tract begin their journey in the neural crest. They termed these cells nexus glia.

But what is the role of these glial cells in the mature heart? When the authors removed the cells, the increased; when the cells were reduced by depriving them of a key gene that drives their glial development, the resulting heart beat irregularly. A major subdivision of the peripheral nervous system, called the autonomic system, regulates many aspects of physiology, including heart rate, through its two branches, the sympathetic and parasympathetic systems. By treating zebrafish with chemicals that increase activity of one branch or another, they showed that cardiac glia control heart rate through their modulation of both branches.

The results greatly expand the understanding of the role of glial cells in the heart and suggest that glia may also play critical roles in the development and function of other organs where they have been glimpsed. "Our findings indicate an extensive and under-explored network of organ-associated glia that have functional roles dependent upon the environment," Smith said. "Further understanding of these specialized astroglial populations is therefore necessary, given their potential impact on organ physiology."

Smith adds, "Astrocyte-like in the PNS are poorly understood. We show that an astrocyte-like cell functions early in development to regulate autonomic-nervous system control of the heart."

More information: Kikel-Coury NL, Brandt JP, Correia IA, O'Dea MR, DeSantis DF, Sterling F, et al. (2021) Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function. PLoS Biol 19(11): e3001444.

Journal information: PLoS Biology
Citation: Little-known glial cells regulate development and function of the heart (2021, November 18) retrieved 19 April 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

New glial cells discovered in the brain: Implications for brain repair


Feedback to editors