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Examining the benefits of creatine for mothers and babies

Examining the benefits of creatine for mum and baby
Volcano plot visualizations of (A) umbilical cord occlusion (UCO) and (B) creatine main effects, and (C) SalUCO vs. CrUCO post-hoc comparisons. Volcano plots show fold change [log2(fold change); i.e., log2(fold change = 2) = 1; x-axis] and all gene expression changes [−log2(adjusted P-value); y axis] in all brain regions: GM (●), WM (■), hippocampus (▲), striatum (◆) and thalamus (▼). Gray dashed line represents a P-value of 0.05 [−log10(0.05)≈4.139]. Names of genes with P < 0.05 are included. Genes that were downregulated are presented in red and those upregulated in blue. (D) Heat map representation of gene expression determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) within saline control (SalCon; n = 5), creatine control (CrCon; n = 7), saline UCO (SalUCO; n = 7) and creatine UCO (CrUCO; n = 6) fetuses. Brain regions analyzed include cortical gray matter (GM); white matter (WM); hippocampus (Hipp); striatum; and thalamus. Red indicates downregulation of mRNA expression; blue indicates upregulation relative to saline controls. Data are average log2 transformed fold change. Credit: Frontiers in Cellular Neuroscience (2023). DOI: 10.3389/fncel.2023.1154772

The benefits of creatine are well known for helping with muscle performance, and now attention has turned to whether it can help mothers and babies have a safer birth.

Restricted to the baby at birth can have severe, long-term impacts including organ damage, , , autism, neurological and mental health disorders, seizures, behavioral issues, ADHD or hearing impairment.

This latest research from a team led by Dr. Stacey Ellery and Dr. Nhi Tran at Hudson Institute of Medical Research, and published in the journal Frontiers in Cellular Neuroscience, tested dietary creatine as a supplement during pregnancy to prevent these problems.

Creatine benefits energy production

Dr. Ellery, who chose to use creatine during her own pregnancy, said there is growing evidence that creatine may be essential for in many facets of conception and maternal health, as well as for the growing and developing baby.

"Creatine is the fuel for the 'backup energy battery' of many vital cells in the brain, so we have been studying its use in cases of energy failure in the fetal brain when oxygen levels drop, and whether this simple supplement can prevent injury," she said.

"The theory is that by providing more charge for this battery through , cells have a greater capacity to maintain energy turnover when oxygen levels drop. This ultimately reduces the build-up of nasty by-products, including and inflammatory molecules, reducing and maintaining brain health."

This is the most comprehensive assessment of the health of multiple cell populations, across several key regions of the fetal brain, following long-term exposure to high creatine in utero and birth asphyxia.

Protective benefits of creatine

And the results suggest that there are protective benefits of creatine to be had, though more research is required.

"Together with the extensive data already produced by our group, it provides evidence to support a clinical trial of dietary creatine in pregnancy, something we are working towards undertaking in the next two-three years once pre-clinical studies and provisional work to ensure an effective dose and safety are finalized," Dr. Ellery said.

"Much like the introduction of folate to reduce neural tube deficits, creatine could become a standard pregnancy supplement to safeguard against poor neurological outcomes in babies. Importantly, this is a treatment that could be accessible for all babies, regardless of their geography or economic circumstances."

More information: Nhi T. Tran et al, Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model, Frontiers in Cellular Neuroscience (2023). DOI: 10.3389/fncel.2023.1154772

Citation: Examining the benefits of creatine for mothers and babies (2023, May 30) retrieved 17 June 2024 from
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