This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


peer-reviewed publication

trusted source


Hypocaloric diet found to attenuate brain changes related to age-associated memory loss

A hypocaloric diet attenuates brain changes related to age-associated memory loss
Hippocampal neurons in development (marked in green) from a young adult rat. Credit: UAB

A study coordinated by the Institute of Neurosciences of the UAB (INc-UAB) analyzes in old rats the effects of a calorie-restricted diet on the hippocampus, a brain structure that is critical in learning and memory processes. The results corroborate that there is a cognitive improvement derived from diet, linked to a reduction in the levels of inflammation and neuronal loss in the hippocampus. The work is published in the journal Nutrients.

Advances in the scientific, technological, and health sectors has led to an increase in in our society and consequently, to a greater incidence of neurodegenerative diseases associated with age. This improvement in life expectancy therefore also requires research into strategies that can delay brain aging.

In this regard, it has been described that some of the brain alterations observed during aging, which may include an increase in and neuroinflammation, alterations in , a reduction in neurogenesis, and a dysregulation of mechanisms involved in , are related to the cognitive dysfunction that manifests naturally as we age. These processes, which depend on both genetic and environmental factors, are particularly important in the hippocampus.

Calorie-restricted diets have been shown to extend life expectancy and improve cognitive status, both in humans and in animal models, but many of the associated with these benefits are still unknown. In this study, coordinated by Professor Gemma Guillazo from the INc-UAB and the Department of Psychobiology and Methodology, and Professor Carlos Barcia from the INc-UAB and the Department of Biochemistry and Molecular Biology, researchers confirm the ability of rats to memorize and learn on calorie-restricted diets compared to rats fed a constant supply of food, and analyzed the effects on the hippocampus.

The results show that the group that followed a hypocaloric diet had better results in the spatial object recognition test, a memory test that allows you to evaluate, among others, the functioning of the hippocampus. In addition, the data obtained suggest that this improvement is linked to a reduction in both age-related neuronal loss and inflammatory activity in this structure.

"This article evidences the effects of the hypocaloric diet in the preservation of hippocampal functions and in the reduction of neuroinflammation associated with aging, and supports interventions at this level to improve the quality of life of elderly people," explains Dr. Guillazo

The study highlights the potential of changes in habits, such as dietary modifications, to promote healthy aging of the brain and prevent age-related cognitive deficits.

More information: Marta Portero-Tresserra et al, Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats, Nutrients (2023). DOI: 10.3390/nu15071572

Journal information: Nutrients
Citation: Hypocaloric diet found to attenuate brain changes related to age-associated memory loss (2023, May 4) retrieved 21 February 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Isoform-specific AMPK repression affects cognitive function in aged mice, researchers find


Feedback to editors