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Medical research
$3.2 million per dose Elevidys fails to meet primary endpoint in phase 3 trial
A Phase 3 clinical trial investigating Elevidys (delandistrogene moxeparvovec), a gene therapy for Duchenne muscular dystrophy, did not achieve its primary endpoint, according to findings published in Nature Medicine. A News ...
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Genetics
Complex genomic variants are related to psychiatric diseases, study finds
The 3 billion base pairs that constitute the human genome—the matching jigsaw puzzle pieces of adenine pairing with thymine and cytosine pairing with guanine—are not just the body's instruction manual. Rearrangements ...
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Medical research news
Custom alterations: Mending genes for long-lasting effects
Gene-editing therapies—techniques that modify DNA to treat or prevent disease—have the potential to transform the field of drug development. By making precise edits to the genome, problematic genes could be modified or ...
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Ultra-short, high-dose proton irradiation enhances cell survival in cancer treatment
Proton beam therapy, a type of radiation therapy, possesses a physical property known as the Bragg peak, which causes the beam to exert its strongest effect at a specific depth, with no effect beyond that point. This characteristic ...
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Clonidine monotherapy as effective as morphine in neonatal opioid withdrawal treatment, study finds
Pediatric researchers at the University of Kentucky found that clonidine, an antihypertensive drug typically used to treat high blood pressure, can be as effective as morphine in treating neonatal opioid withdrawal syndromes ...
Study reveals how fear memories transform over time, offering new insights into PTSD
An innovative study, published in Nature Communications, reveals the mechanism behind two seemingly contradictory effects of fear memories: the inability to forget yet the difficulty to recall.
5 hours ago
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National poll: Many teens use protein supplements for muscle growth, sports performance
Protein bars, shakes and powders are increasingly popular among adults—but many teens may be jumping on the bandwagon too.
10 hours ago
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Alzheimer's disease may damage the brain in two phases
Alzheimer's disease may damage the brain in two distinct phases, based on new research using sophisticated brain mapping tools. According to researchers who discovered this new view, the first, early phase happens slowly ...
23 hours ago
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Study explores how acoustic elements influence perceptions of music being out of tune
When we listen to a song or musical performance, out-of-tune singers or instruments are generally perceived as unpleasant for listeners. While it is well-established that mistuning can reduce the enjoyment of music, the processes ...
Meta-analysis reveals minimal cognitive gains from antipsychotic drugs
A systematic review and network meta-analysis of 68 studies has found no clear evidence that any specific antipsychotic significantly improves cognitive function in patients with schizophrenia spectrum disorders compared ...
Glucose metabolism drives embryonic development in mice, study reveals
Yale University researchers have discovered that glucose metabolism plays a critical role in guiding the early development of mouse embryos, revealing that specific metabolic pathways regulate essential cell signaling during ...
Large study finds prolonged fasting for multiple orthopedic surgeries raises risk of malnutrition, worse outcomes
People who have multiple orthopedic surgeries during the same hospital stay are more likely to suffer malnutrition due to repeated or prolonged fasting, which can slow recovery and increase the risk of death, according to ...
Oct 19, 2024
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Learning without feedback: Neuroscientist helps uncover the influence of unsupervised learning on humans and machines
Imagine a child visiting a farm and seeing sheep and goats for the first time. Their parent points out which is what, helping the child learn to distinguish between the two. But what happens when the child does not have that ...
Oct 18, 2024
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Study shows that Rett syndrome in females is not just less severe, but different
A new UC Davis MIND Institute study offers critical insights into Rett syndrome, a rare genetic condition that affects mostly girls. The research reveals how this condition affects males and females differently, with symptoms ...
Oct 18, 2024
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Discovery of how liver flushes cholesterol from body could lead to better cardiovascular disease treatments
A new discovery about how the liver flushes cholesterol from the body could lead to more effective treatments for cardiovascular disease—the leading cause of death worldwide.
Oct 18, 2024
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Researchers identify molecular mechanism that could help design future therapies to treat Alzheimer's disease
A research team at the Institute of Neurosciences of the University of Barcelona (UBneuro) has led a study describing a new molecular mechanism that affects RNA processing and alters the process of protein synthesis in the ...
Oct 18, 2024
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Black adults disproportionately affected as glaucoma reaches 4.22 million in the US
A University of Michigan led study finds regional and demographic disparities in glaucoma burden. Results find that 4.22 million U.S. adults had glaucoma in 2022, with 1.49 million living with vision impairment.
In vitro model helps show why breast cancer spreads to bone
Researchers from Tampere University, Finland, and Izmir Institute of Technology, Turkey, have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing ...
Oct 18, 2024
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Genetic mapping study uncovers four main categories of cancer drug resistance mutations
All cancer mutations that cause drug resistance fall into one of four categories. New research has detailed each type, helping to uncover targets for drug development and identify potential effective second-line therapies.
Oct 18, 2024
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Solving a 50-year-old mystery could lead to neurodegenerative disease treatments
Scientists have gained a deeper understanding of a molecule that regulates lipid levels in the brain. This breakthrough could eventually lead to treatments for diseases like frontotemporal dementia and Alzheimer's disease. ...
Oct 18, 2024
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