Journal of Clinical Investigation

Diseases, Conditions, Syndromes

Prevention of sickle cell disease progression in adult mice

Sickle cell disease (SCD) is characterized by abnormal hemoglobin, which alters the shape of red blood cells, resulting in poor blood flow and eventual death. In developed countries, the survival rate in children with SCD ...


Study identifies mechanisms underlying osteochondroma formation

Osteochondromas are cartilage-capped benign bone tumors that form on the surface of bones near growth plates. These growths typically occur in adolescents and can result in growth impairment, pain, and fractures. In hereditary ...


Combination therapy for acute lymphoblastic leukemia

A subset of acute lymphoblastic leukemia (ALL) patients is positive for the Philadelphia chromosome, which is generated by a specific translocation event that causes a fusion between the BCR and ABL1 genes. These patients ...

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