Page 12 - Journal of Clinical Investigation

Immunology

Liver tropism is key for B cell deletion immunotherapy

Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 ...

Diseases, Conditions, Syndromes

Identifying targets of autoantibodies

Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. The host factors that are targeted by autoantibodies produced by SLE patients ...

Medical research

Bone loss associated with increased production of ROS

Bone is constantly being broken down and remodeled. Osteoporosis results when bone resorption outpaces bone regeneration. Production of reactive oxygen species, a form of oxidative stress, has been predicted to promote bone ...

Medical research

Exploring the cause of sudden unexplained death in epilepsy

Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from ...

Oncology & Cancer

Combination therapy for acute lymphoblastic leukemia

A subset of acute lymphoblastic leukemia (ALL) patients is positive for the Philadelphia chromosome, which is generated by a specific translocation event that causes a fusion between the BCR and ABL1 genes. These patients ...

Oncology & Cancer

Improving models of chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a common form of adult leukemia that results in the progressive expansion of abnormal lymphocytes. The cell type that gives rise to CLL is still unclear, though evidence suggests that ...

Medical research

Genotype influences muscle performance

Elite endurance athletes commonly have mutations that result in the loss of the protein α-actinin-3, which is a major component of fast-twitch muscle fibers. Loss of α-actinin-3 is associated with reduced power, increased ...

Arthritis & Rheumatism

Resolvin D1 ameliorates inflammatory arthritis in mouse model

Rheumatoid arthritis (RA) is a debilitating autoimmune disorder that is characterized by the accumulation of inflammatory cells within the fluid of the joints. Current therapeutic strategies mostly serve to ease pain and ...

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