Rheumatoid arthritis (RA) is a debilitating autoimmune disorder that is characterized by the accumulation of inflammatory cells within the fluid of the joints. Current therapeutic strategies mostly serve to ease pain and ...
Apr 21, 2016
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Elite endurance athletes commonly have mutations that result in the loss of the protein α-actinin-3, which is a major component of fast-twitch muscle fibers. Loss of α-actinin-3 is associated with reduced power, increased ...
Sep 16, 2013
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Ischemic stroke is characterized by an interruption of the blood supply to the brain, which can lead to brain damage and even death. Excess amounts of the excitatory neurotransmitter glutamate are released during stroke events ...
Sep 3, 2013
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Demyelinating diseases, such as multiple sclerosis (MS), are frequently associated with the progressive loss of vision. The retinal nerve damage is thought to be caused by immune system-mediated inflammation; however, other ...
Jan 2, 2013
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Large-scale genetic studies have linked variations in genes and proteins to an increased risk for developing obesity. Determining how these variations alter metabolism to increase body mass may lead to the identification ...
Jun 20, 2016
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Sustained pathological remodeling of the heart after injury is associated with increased risk of heart failure and death. Several recent studies have shown that strategies to reduce heart failure are associated with a reversal ...
Apr 7, 2016
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Breast cancer can be divided into 4 major subtypes using molecular and genetic information from the tumors. Each subtype is associated with different prognosis and should be taken into consideration when making treatment ...
Sep 3, 2013
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The microbiome of the human intestine consists of a variety of bacteria that assist in digestion, immune regulation, and other processes that are critical for human health. A subset of these bacteria produces urease, an enzyme ...
Jun 22, 2015
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The accumulation of amyloid-β (Aβ) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of Aβ pathogenesis is not fully understood.
Jun 10, 2013
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Deletion of a protein in white blood cells improves their ability to fight the bacteria staphylococcus aureus and possibly other infections in mice with chronic granulomatous disease (CGD), according to a National Institutes ...
Aug 1, 2013
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