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Dietary compound increases longevity and protects against Alzheimer's disease in experimental models
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Dietary compound increases longevity and protects against Alzheimer's disease in experimental models
Researchers from the Color and Food Quality group at the Faculty of Pharmacy (University of Seville), in collaboration with Dr. Marina Ezcurra's group at the University of Kent (U.K.), have shown that the carotenoid phytoene ...
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Promising drug combo targets aggressive bladder cancers
A new study in mice by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) has identified a promising drug combination for the treatment of muscle-invasive bladder cancer. Rosiglitazone plus trametinib worked ...
Sep 25, 2024
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How AI is helping to bridge the research gap between animals and humans
The transfer of knowledge from animal models to humans is essential for unraveling disease mechanisms and developing precise therapeutic strategies. The high-resolution method of single-cell RNA sequencing makes it possible ...
Sep 25, 2024
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Researchers create mouse model to mimic Parkinson's disease
Researchers at the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children's Hospital and Baylor College of Medicine recently made an important advance in neurodegenerative disease research and modeling. ...
Sep 25, 2024
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Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections
A new study details how a nasal spray formulated by investigators from Brigham and Women's Hospital may work to protect against viral and bacterial respiratory infections. Based on their preclinical studies, the researchers ...
Sep 25, 2024
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Scientists investigate a potential anti-aging drug that could preserve proteasomes and autophagy systems
Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental ...
Sep 25, 2024
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Key molecular targets for wound healing identified
Novel research, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, has identified key molecular targets that could significantly enhance the healing of both acute and chronic wounds.
Sep 25, 2024
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Blueberry-derived compound shows promise in enhancing colonic mucosal barrier function
A research team from Shenyang Agricultural University, led by Dr. Bin Li, has highlighted the potential of malvidin-3-O-galactoside (M3G), a blueberry-derived anthocyanin, to improve colonic mucosal barrier function and alleviate ...
Sep 25, 2024
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Ru5 identified as potent antitumor agent targeting mitochondrial ATPase
A research team identified Ru5 as a potent antitumor agent by screening a panel of ruthenium(II) polypyridine complexes containing β-carboline derivatives as ligands. By employing a photoaffinity tag and utilizing the photoaffinity-based ...
Sep 25, 2024
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Reduced sialylation of mucin impairs mucus transport in lungs, study shows
With each breath, a human may inhale thousands of harmful microbes into the lungs. Mucus, the gel-like moist substance coating the airways, is one of the first lines of defense and aids in removal of these microbes. It entraps ...
Sep 24, 2024
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Clinical trial: Cholesterol drug ineffective for treatment of multiple sclerosis
Results of a world-first phase 3 trial for secondary progressive multiple sclerosis (MS), led by UCL researchers, have shown that the commonly used high-cholesterol drug simvastatin cannot slow disability progression.
Sep 24, 2024
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Review of performance measures for pain finds those for acute pain treatment lacking
A review by the American College of Physicians (ACP) of performance measures designed to evaluate quality of care for those adults suffering from pain found three of six measures relevant to internal medicine physicians to ...
Sep 24, 2024
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Fibrosis lacks treatments and methods of reversal: Study pinpoints a promising target for drug therapy
Medical science has long been on the hunt for a deeper understanding of the devastating scarring of the body's organs known as fibrosis, which leads to irrevocable loss of function.
Small-molecule drug shows potential for hard to treat cancers
Experts from the University of of Dundee's Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a "protein degrader."
Sep 23, 2024
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Tackling antimicrobial resistance with non-antibiotic therapeutic approaches and AI
Artificial intelligence and non-antibiotic therapeutic approaches could play a role in tackling antimicrobial resistance (AMR), according to new research.
Sep 23, 2024
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Understanding sex-specific differences in aortic aneurysms
A group of researchers at the University of Kentucky have found a mechanism that would explain why men develop more aortic aneurysms than women.
Sep 23, 2024
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Clinical trial supports adding ruxolitinib to tyrosine kinase inhibitors for chronic myeloid leukemia
Researchers leading the SWOG S1712 clinical trial have found that adding ruxolitinib to standard tyrosine kinase inhibitor (TKI) treatment for patients with chronic-phase chronic myeloid leukemia (CP-CML) significantly increased ...
Sep 23, 2024
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EU capacity for antibiotic research and development requires long-term funding, say researchers
Antibiotic resistance is a global public health threat. Modern health systems rely on antibiotics to prevent and treat infections, and the need for new drugs is urgent. In a joint call to action, the AMR Accelerator projects ...
Sep 23, 2024
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Novel drug molecule could help treat Parkinson's disease in young patients
More than 100,000 Canadians currently live with Parkinson's disease. A novel drug molecule being studied by researchers from McGill University could reactivate housekeeping functions in brain cells of young Parkinson's patients, ...
Sep 19, 2024
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New ventilator-on-a-chip model enables real-time detection of lung injury at cellular level
For the first time, scientists are able to directly compare the different kinds of injury that mechanical ventilation causes to cells in the lungs.
Sep 19, 2024
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Researchers discover potential target to treat severe anemia in patients unresponsive to standard treatments
Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO) increases, leading to the proliferation ...
Sep 19, 2024
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Study warns high serum magnesium levels in septic patients linked to increased mortality
Sepsis is one of the most common life-threatening conditions in intensive care units, with approximately 48.9 million cases reported worldwide in 2017, accounting for 19.7% of total global mortality. Given the severity of ...
Sep 19, 2024
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Ground squirrel study points to potential development of a cataract drug
Researchers at the National Institutes of Health (NIH) and their collaborators have identified a protein, known as RNF114, that reverses cataracts, a clouding of the eye's lens that occurs commonly in people as they age. ...
Sep 18, 2024
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Molecular pathway discovery points to a way to modulate scarring in spinal cord injury
After a spinal cord injury, nearby cells quickly rush to action, forming protective scar tissue around the damaged area to stabilize and protect it. But over time, too much scarring can prevent nerves from regenerating, impeding ...
Sep 18, 2024
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