Cardiology

A leap in understanding of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common of all genetic heart diseases and is the leading cause of sudden cardiac death. It is characterized by an abnormal thickening of the heart muscle, which over time can lead ...

Medical research

Shootin1a—the missing link underlying learning and memory

In neurons, changes in the size of dendritic spines—small cellular protrusions involved in synaptic transmission—are thought to be a key mechanism underlying learning and memory. However, the specific way in which these ...

Medical research

Changing the perspective on the 'Cinderella of the cytoskeleton'

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated or lost in several cancer ...

Oncology & Cancer

Form drives function in cancer proliferation

A new study finds that the protein responsible for the crawling movements of cells also drives the ability of cancer cells to grow when under stress.

Medical research

Researchers find new way to force stem cells to become bone cells

Imagine you have a bone fracture or a hip replacement, and you need bone to form, but you heal slowly – a common fact of life for older people. Instead of forming bone, you could form fat. Researchers at the University ...

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