(Medical Xpress)—In the battle against aging and age-related neurological diseases such as Parkinson's and Alzheimer's, a key factor has long appeared to be the toxicity of proteins which tend to aggregate. Recently, scientists ...
In experiments in mice, Johns Hopkins Medicine researchers say they have found additional evidence that Parkinson's disease originates among cells in the gut and travels up the body's neurons to the brain. The study, described ...
Jun 26, 2019
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A new study finds that a protein key to Parkinson's disease has likely been mischaracterized. The protein, alpha-synuclein, appears to have a radically different structure in healthy cells than previously thought, challenging ...
Aug 14, 2011
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A pair of recent studies led by Joseph Mazzulli, Ph.D., associate professor in The Ken & Ruth Davee Department of Neurology's Division of Movement Disorders, have uncovered previously unknown cellular mechanisms involved ...
Jul 1, 2024
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In studies with genetically engineered mice, Johns Hopkins Medicine researchers say they have identified a potentially new biological target involving Aplp1, a cell surface protein that drives the spread of Parkinson's disease-causing ...
Jun 17, 2024
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Scientists have identified a molecule that can prevent tangling of a brain protein that is linked to diseases such as Parkinson's. The findings may provide insights into new ways of treating or diagnosing the early stages ...
Sep 27, 2023
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After Alzheimer's, Parkinson's is the most common neurodegenerative disease in the world. More than six million people worldwide suffer from it. In this disease, alpha-synuclein proteins form thread-like structures called ...
Nov 15, 2022
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One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians ...
Jun 9, 2022
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In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson's ...
May 19, 2022
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A novel system to control protein aggregation in a model of Parkinson's disease may answer longstanding questions about how the disease begins and spreads, according to a new study published March 9 in the open-access journal ...
Mar 22, 2022
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