A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism—the sum of all life-sustaining chemical reactions.
Jul 8, 2024
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Each cell contains a set of instructions in its DNA that determines which genes are expressed and which are silenced. The correct programming of these so-called epigenetic programs, including DNA methylation, is essential ...
Jun 11, 2024
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Exercise—it's associated with increased muscle strength, improved heart health, lower blood sugar and just about every other physical improvement you can name. But how does regularly puffing away on a treadmill, biking ...
May 14, 2024
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Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming. This discovery potentially opens up new avenues for cancer treatments that ...
May 3, 2024
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Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms. People with the disease have much reduced life expectancy and suffer from facial deformities; growth failure; neurological, ...
Apr 10, 2024
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There is strength in teamwork, and it turns out that this applies to tumors, too. Researchers from Japan have reported that different types of cells within a single benign tumor may work together to promote the tumor's growth.
Mar 1, 2024
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Surveys show most men in the United States are interested in using male contraceptives, yet their options remain limited to unreliable condoms or invasive vasectomies. Recent attempts to develop drugs that block sperm production, ...
Feb 20, 2024
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Tumors depend heavily on certain genetic changes to thrive, and researchers have discovered many such "genetic dependencies" as targets for potential new cancer drugs. At the Broad Institute of MIT and Harvard and elsewhere, ...
Jan 23, 2024
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During oxidative stress, excess production of reactive oxygen species causes cell and tissue damage.
Dec 21, 2023
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Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast ...
Dec 8, 2023
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