Health

Eight ways chemical pollutants harm the body

A new review of existing evidence proposes eight hallmarks of environmental exposures that chart the biological pathways through which pollutants contribute to disease: oxidative stress and inflammation, genomic alterations ...

Medical research

New findings help explain how COVID-19 overpowers the immune system

Seeking to understand why COVID-19 is able to suppress the body's immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 ...

Neuroscience

Scientists develop new gene therapy for eye disease

Scientists from Trinity College Dublin have developed a new gene therapy approach that offers promise for one day treating an eye disease that leads to a progressive loss of vision and affects thousands of people across the ...

Medical research

Increasing food intake by swapping mitochondrial genomes

Many of the characteristics that make people so different from each other are often the result of small differences in the DNA between individuals. Variation in just a single base in our DNA can cause significant variation ...

Medications

Potential drug targets for ALS and FTD identified in two studies

A pair of collaborative studies led by Fen-Biao Gao, Ph.D., have identified two potential drug targets for the diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The studies, which appear in Nature ...

Oncology & Cancer

Gene fusion shifts cell activity into high gear, causing some cancer

The fusion of two adjacent genes can cause cancer by kicking mitochondria into overdrive and increasing the amount of fuel available for rampant cell growth, researchers at Columbia University Medical Center (CUMC) have discovered. ...

Alzheimer's disease & dementia

Power outage in the brain may be source of Alzheimer's

On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms. Her behavior is erratic. She shows signs of paranoia as well as auditory hallucinations, ...

Genetics

Unravelling the genetic mystery behind mitochondrial disease

Researchers from the Monash Biomedicine Discovery Institute in Melbourne have identified two new genes linked to a major cause of mitochondrial disease. Their research opens the way for better genetic diagnosis of the disease ...

Genetics

Genetic switch could be key to increased health and lifespan

Newly discovered genetic switches that increase lifespan and boost fitness in worms are also linked to increased lifespan in mammals, offering hope that drugs to flip these switches could improve human metabolic function ...

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