Oncology & Cancer

Heart medication converts cancer cells into vaccine

(HealthDay) -- A class of heart medications, cardiac glycosides, can induce immunogenic cell death (ICD), whereby dying cancer cells are converted into a vaccine that stimulates antitumor response, according to a study published ...

Neuroscience

How synaptic vesicles accumulate glutamate

In the brain, neurons communicate via neurotransmitters, which trigger electrical signals in downstream neurons by binding and activating specific receptors. Neurotransmitters are released through the fusion of synaptic vesicles, ...

Immunology

New target identified to combat deadly allergic reactions

Researchers in France have identified a molecular motor that controls the release of inflammatory factors that cause severe and fatal allergic reactions. The study, "Kinesin-1 controls mast cell degranulation and anaphylaxis ...

Medical research

Cholesterol sets off chaotic blood vessel growth

A study at the University of California, San Diego School of Medicine identified a protein that is responsible for regulating blood vessel growth by mediating the efficient removal of cholesterol from the cells. Unregulated ...

Immunology

Rescue protein gives doomed cells a stay of 'execution'

A research team led by St. Jude Children's Research Hospital immunologists has discovered how a set of proteins delays the "executioner" machinery that kills damaged or infected cells in a process called necroptosis. The ...

Medical research

Understanding and improving the body's fight against pathogens

Scientists from A*STAR's Bioprocessing Technology Institute (BTI) have uncovered the crucial role of two signalling molecules, DOK3 and SHP1, in the development and production of plasma cells. These discoveries, published ...

Diabetes

Telmisartan reverses insulin resistance in mice

(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, according to ...

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