InSysBio continues to investigate the mechanisms underlying Alzheimer's disease (AD) using the quantitative systems pharmacology (QSP) modeling approach. The QSP model describing the tau protein was published in PLOS ONE.
Feb 28, 2018
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Deep within our brains is a dense forest of 100 billion nerve cells. Each of those cells has about 15,000 dendrites that branch out to connect with dendrites from other nerve cells, generating more than 100 trillion points ...
Nov 16, 2017
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In the brains of people with Alzheimer's disease, there are abnormal deposits of amyloid beta protein and tau protein, and swarms of activated immune cells. But scientists do not fully understand how these three major factors ...
Aug 29, 2017
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The hallmark of many neurodegenerative diseases is the formation of protein aggregates, yet how and why these aggregates form remains a mystery. In a study publishing 6 July in the open access journal PLOS Biology by the ...
Jul 6, 2017
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Tau proteins are involved in more than twenty neurodegenerative diseases, including various forms of dementia. These proteins clump together in patients' brains to form neuronal tangles: protein aggregation that eventually ...
May 19, 2017
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A research team from the University of Plymouth, University of Southampton and the Alexander Fleming Biomedical Sciences Research Center, Vari, Greece, have studied two structurally-similar proteins in the adult brain and ...
May 19, 2017
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Nagoya University-led research identifies role for neuronal protein interaction in preventing frontotemporal lobar degeneration, a dementia that starts in middle age.
Feb 13, 2017
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A discovery of high relevance in medical research will be published in Volume 55, number 4 of December 2016 of the prestigious "Journal of Alzheimer's Disease (JAD)", entitled "Tau Platelets Correlate with Regional Brain ...
Dec 22, 2016
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A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer's disease begins within the brain. The researchers found a relationship between inflammation, a toxic protein ...
Nov 18, 2016
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Tangled up brain fibrils made up of a rogue protein known as tau are the hallmark of Alzheimer's disease (AD) that likely hold the key to treatments, making them of great interest to researchers. Mimicking the formation and ...
Nov 16, 2016
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