By engineering cells to express a modified RNA called "Spinach," researchers have imaged small-molecule metabolites in living cells and observed how their levels change over time. Metabolites are the products of individual ...
Mar 8, 2012
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St. Jude Children's Research Hospital scientists led a study showing that mutations in a gene responsible for amyotrophic lateral sclerosis (ALS) disrupt the RNA transport system in nerve cells. The findings appear in the ...
Feb 5, 2014
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Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are degenerative motor neuron diseases in which the key mutated genes are involved in RNA metabolism. This similarity suggests that a common dysregulation ...
Apr 26, 2013
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A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It produces collagen to repair damaged cells when the liver is injured. However, a liver can produce too much collagen when an excess ...
Apr 26, 2024
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(Medical Xpress) -- A protein essential for metabolism and recently associated with neurodegenerative diseases also occurs in several brain-specific forms. This discovery emerged in the course of a research project funded ...
Jul 23, 2012
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(HealthDay)—A group of metabolites whose levels decline as people age appear to have an effect on the circadian clock, according to a study published online Oct. 8 in Cell Metabolism.
Oct 19, 2015
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In Leigh syndrome, infants are born apparently healthy only to develop movement and breathing disorders that worsen over time, often leading to death by the age of 3. The problem is that the mitochondria responsible for powering ...
Sep 6, 2011
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(HealthDay)—A plasma assay that detects dysregulated lipids has potential as a screening method for early-stage lung cancer, according to a study published in the Feb. 2 issue of Science Translational Medicine.
Feb 3, 2022
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Muscles consume a large part of the body's energy. Hence when fat metabolism in muscle cells is impaired, the organism gains weight. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have ...
Apr 13, 2017
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(Medical Xpress)—A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, ...
Mar 18, 2013
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