Oncology & Cancer

Splicing factor to blame in triple negative breast cancer

If your DNA is a cookbook, a single gene is a recipe. But it's a flexible recipe that if edited one way can make a pie; edited another way can make a cake. And that difference can mean cancer, as a team of researchers who ...

Neuroscience

Tau-mediated RNA splicing errors linked to Alzheimer's disease

A collaborative study published today in the journal Cell Reports provides evidence for a new molecular cause for neurodegeneration in Alzheimer's disease. The study, led by researchers at Baylor College of Medicine and the ...

Oncology & Cancer

New way to target cancer's diversity and evolution

Scientists have revealed close-up details of a vital molecule involved in the mix and match of genetic information within cells—opening up the potential to target proteins of this family to combat cancer's diversity and ...

Neuroscience

Unique fingerprint: What makes nerve cells unmistakable?

Protein variations that result from the process of alternative splicing control the identity and function of nerve cells in the brain. This allows organisms to build a highly complex neuronal network with only a limited number ...

Neuroscience

A match made in neural heaven: How a neuron grows an axon

While the neural architecture responsible for the transmission of electrical impulses has been known for more than a century, the basic biology behind how a neuron acquires its one and only axon—a fundamental component ...

Oncology & Cancer

Mechanism explains breast cancer cell plasticity

One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment. Understanding the cellular mechanisms that mediate this cancer cell plasticity ...

Genetics

Unraveling a genetic network linked to autism

Donnelly Centre researchers have uncovered a genetic network linked to autism. The findings, described in the journal Molecular Cell, will facilitate developing new therapies for this common neurological disorder.

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