So far, it has not been possible to explain the causes of around half of all rare hereditary diseases. A Munich research team has developed an algorithm that predicts the effects of genetic mutations on RNA formation six ...
Jun 1, 2023
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Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, ...
May 17, 2023
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Why do some people with a genetic mutation associated with leukemia remain healthy, while others with the same mutation develop the blood cancer? In a new study published in Blood, scientists from the USC Stem Cell laboratory ...
Mar 23, 2023
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Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome (MDS) patients. In a study ...
Mar 21, 2023
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A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
Living organisms have a knack for persisting in the face of challenges. For instance, when genes malfunction, organisms may be able to compensate by activating redundant genes with similar functions, called paralogs.
Feb 21, 2023
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When cells copy DNA to produce RNA transcripts, they include only some chunks of genetic material known as exons and throw out the rest. The resulting product is a fully-mature RNA molecule, which can be used as a template ...
Feb 9, 2023
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The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To this end, researchers from ...
Nov 18, 2022
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Researchers have puzzled over the neurodegenerative disorder Alzheimer's disease for decades, but treatments to stop or reverse the disease's effects on the brain have remained elusive. Scientists at St. Jude Children's ...
Oct 13, 2022
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Researchers from Barts Cancer Institute (BCI) at Queen Mary University of London, the Italian Institute for Genomic Medicine, and the University of Milan have identified a novel role for a cancer-causing gene in controlling ...
Sep 27, 2022
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