Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 ...
Nov 1, 2013
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The human brain is composed of complex circuits of neurons, cells that are specialized to transmit information via electrochemical signals. Like the circuits in a computer, these neuronal circuits must be connected in particular ...
Dec 17, 2015
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The flu has been our viral companion for millennia, but its capricious behavior continues to confound scientists and public health experts.
Feb 9, 2018
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The influenza virus is an annual threat to public health around the world. Rapid changes in viral surface proteins (antigens), however, make it difficult to identify antibodies with broadly neutralizing activity against different ...
Feb 1, 2019
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Many proteins at the cell surface are 'decorated' with carbohydrate molecules called glycans. Changes in a cell's glycan profile can greatly alter how it behaves and interacts with its environment, and abnormalities in this ...
Jan 29, 2014
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In studies with genetically engineered mice, Johns Hopkins Medicine researchers say they have identified a potentially new biological target involving Aplp1, a cell surface protein that drives the spread of Parkinson's disease-causing ...
Jun 17, 2024
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A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future.
Mar 8, 2018
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Nearly half of HIV infected patients suffer from impaired neurocognitive function. The HIV protein transactivator of transcription (Tat) is an important contributor to HIV neuropathogenesis because it is a potent neurotoxin ...
Jan 29, 2016
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A newly found understanding of receptor signaling may have revealed a better way to design drugs. A study from Nationwide Children's Hospital suggests that a newly identified group of proteins, alpha arrestins, may play a ...
Dec 10, 2012
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Researchers at University of Copenhagen have gained more insight into the molecular mechanisms of importance for, for example, cancer cell growth and metastasis. The research objective is improved and more targeted drugs. ...
Sep 25, 2013
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