Oncology & Cancer

Tumors disable immune cells by using up sugar

Cancer cells' appetite for sugar may have serious consequences for immune cell function, researchers at Washington University School of Medicine in St. Louis have learned.

Oncology & Cancer

Cancer cell metabolism kills

Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply can be fatal ...

Oncology & Cancer

Scientists find potential loophole in pancreatic cancer defenses

Dana-Farber Cancer Institute scientists and colleagues have discovered that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control ...

Oncology & Cancer

Cancer suppressor gene links metabolism with cellular aging

The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...

Oncology & Cancer

Breast cancer risk linked to early-life diet and metabolic syndrome

Striking new evidence suggesting that diet and related factors early in life can boost the risk for breast cancer—totally independent of the body's production of the hormone estrogen—has been uncovered by a team of researchers ...

Oncology & Cancer

Chemists determine one way tumors meet their growing need

Behaving something like ravenous monsters, tumors need plentiful supplies of cellular building blocks such as amino acids and nucleotides in order to keep growing at a rapid pace and survive under harsh conditions. How such ...

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